Publication Date:
2012-02-29
Description:
Bacteria commonly encode virulence determinants that mediate the disruption of host cell membranes; however, vacuole lysis and invasion of the host cell cytosol is a strategy used by only a select few bacterial pathogens for intracellular replication (1). Many bacterial pathogens replicate in specialized vacuoles that must be actively maintained to prevent these organelles from fusing with lysosomes and to regulate acquisition of new membrane for vacuole expansion during bacterial replication (2). However, why is this, when, in theory, it should be easier for a bacterium to lyse the vacuole and replicate in the cytosol? A study in PNAS provides...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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