ISSN:
0009-2940
Keywords:
Oxacyclooctynes
;
Ring strain
;
Selenadiazole fragmentation
;
Calculations, MNDO
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
1-Oxa-3-cyclooctyneAccording to an MNDO calculation, 1-oxa-cyclooctyne (13) and 1-oxa-3-cyclooctyne (14) are 8-membered heterocyclic ring systems with high steric energy (ring strain). On the basis of THF (1) and acetoacetic ester (4), a multi-step synthesis is described for 14. The triple bond is introduced in the last step by a thermal fragmentation of the 1,2,3-selenadiazole 12.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19901230634
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