ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The optically pure steroid (+)-15 has been synthesized from the easily accessible (+)-carboxylic acid 11 by a sequence of 7 steps in 50% overall yield. The key steps are the regioselective deprotonation/alkylation 7+13 → 14 and the thermal SO2-extrusion/cycloaddition 14 → 15 (Scheme 3). The compound (+)-15 has been readily converted to the naturally occurring (+)-estradiol (17) in 60% yield.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19800630638
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