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  • 1
    Electronic Resource
    Electronic Resource
    Investigations into the mechanism of hormone release by rat adrenocortical cells (1978)
    Springer
    Cell & tissue research 189 (1978), S. 403-407 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal gland ; Rat ; Vinblastine ; Corticosterone ; Exocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Vinblastine treatment blocks corticosterone release from rat adrenal zona fasciculata without impairing hormone synthesis, and induces the formation of acid phosphatase-positive granular clumps at the juxta-sinusoidal pole of the cells. Autoradiography shows that ACTH administration to vinblastine-treated animals mobilizes the 3H-cholesterol stored in the lipid droplets and leads to a noticeable labelling of the granular clumps. The possible significance of these granules is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209129
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  • 2
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1980)
    Springer
    Cell & tissue research 210 (1980), S. 333-337 
    Details
    ISSN: 1432-0878
    Keywords: Zona glomerulosa ; Angiotensin II ; Mitochondria ; Stereology ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of a chronic treatment with angiotensin II (up to 15 consecutive days) on the mitochondria of the rat zona glomerulosa cells were investigated by electron microscopic and stereological methods. Angiotensin induced a significant increase in the volume of the mitochondrial compartment. Up to the 3rd day of treatment this was due only to the hypertrophy of the organelles, and from the 3rd to the 15th day exclusively to mitochondrial proliferation. The hypothesis that angiotensin controls the growth and proliferation of rat zona glomerulosa mitochondria is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237620
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  • 3
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1976)
    Springer
    Cell & tissue research 172 (1976), S. 149-156 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; Ultrastructure ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The radioactivity decay of the mitochondrial compartment of 3H-thymidine-injected rats was followed by high resolution autoradiography. The number of days in which the radioactivity of the mitochondrial compartment is reduced to a half was calculated from the semilogarithmic plots of radioactivity versus time. Since DNA is a very stable molecule, it was assumed that this parameter can be an estimate of the half-life of adrenocortical mitochondria. It was found that the half-lives of mitochondria from the zonae glomerulosa, fasciculata and reticularis are, respectively, 8.20, 11.51 and 8.16 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226023
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  • 4
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1976)
    Springer
    Cell & tissue research 168 (1976), S. 1-9 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; ACTH ; Stereology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of ACTH (up to 36 consecutive days) on the mitochondria of the zona reticularis of the rat adrenal cortex were investigated by stereologic techniques. It was found that ACTH induces two phases of hypertrophy of mitochondria alternating with two proliferative stages, which are associated with a significant decrease in the average volume of the organelles. It is suggested that, as in the zona fasciculata, ACTH controls the processes of growth and division of mitochondria in the zona reticularis. The mechanism underlying this action of ACTH as well as the differences between the responses to ACTH of the mitochondrial population of the two adrenal zones are discussed in the light of evidence indicating that mitochondria contain a complete genetic apparatus largely independent of nuclear control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219719
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  • 5
    Electronic Resource
    Electronic Resource
    An electron-microscopic stereological study of the compensatory hypertrophy of the rat adrenal zona fasciculata after unilateral adrenalectomy (1982)
    Springer
    Cell & tissue research 225 (1982), S. 455-459 
    Details
    ISSN: 1432-0878
    Keywords: Monoadrenalectomy ; Compensatory adrenal growth ; Zona fasciculata ; Rat ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The ultrastructural changes associated with the compensatory hypertrophy of the zona fasciculata cells on monoadrenalectomized rats were investigated by stereological techniques. It was found that these subcellular changes display a different pattern from those underlying the ACTH-induced adrenocortical cell growth in the intact rats. This result supports the view that compensatory adrenal hypertrophy does not involve activation of the hypothalamo-hypophyseal-adrenal axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214697
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of prolonged treatment with cyanoketone on the zona fasciculata of rat adrenal cortex (1987)
    Springer
    Cell & tissue research 250 (1987), S. 599-605 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Cyanoketone ; Corticosterone ; Morphometry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of a 7-day administration of cyanoketone (CKT) on the adrenal zona fasciculata were examined in “normal” and dexamethasone/ACTH-infused rats. The drug caused a 48–56% decrease in the blood concentration of corticosterone, coupled with a 53–58% lowering in the activity of 3β-hydroxysteroid dehydrogenase (3βHSD), in both groups of animals. In the “normal” rats, CKT induced a significant hypertrophy of the zona fasciculata and its parenchymal cells, due to an increase in volume of the mitochondrial compartment and to proliferation of the smooth endoplasmic reticulum (SER), as well as a notable rise in both the volume of the lipid-droplet compartment and the intracellular concentration of total cholesterol. The activity of 11β-hydroxylase was conspicuously enhanced. All these responses of zona fasciculata cells to CKT did not occur in dexamethasone/ACTH-treated animals, and therefore they were considered to be non-specific and mediated by the augmented secretion of ACTH following lowering of the corticosterone level in the blood. In the dexamethasone/ACTH-infused rats, the only morphological change induced by CKT was a significant decrease in the surface area per cell and surface density of the SER, which was interpreted as the morphological counterpart (not masked by the increased level of circulating ACTH) of the drug-induced inhibition of the microsomal 3βHSD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218953
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  • 7
    Electronic Resource
    Electronic Resource
    Morphometric investigations into the mechanism of the compensatory hypertrophy of the rat adrenal zona fasciculata after unilateral adrenalectomy (1983)
    Springer
    Cell & tissue research 234 (1983), S. 573-578 
    Details
    ISSN: 1432-0878
    Keywords: Adrenalectomy ; Hypophysectomy ; Compensatory adrenal growth ; Rat ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Compensatory hypertrophy of the remaining gland in unilaterally adrenalectomized rats was investigated by morphometric techniques. It was observed that compensatory adrenal growth occurred in both dexamethasone-treated and hypophysectomized rats, receiving maintenance doses of ACTH. However, it was only half that found in intact animals. These results support the view that activation of the hypothalamo-hypophyseal axis is not the unique mechanism underlying adrenal compensatory hypertrophy in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218652
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  • 8
    Electronic Resource
    Electronic Resource
    Short- and long-term effects of ACTH on the adrenal zona glomerulosa of the rat (1986)
    Springer
    Cell & tissue research 243 (1986), S. 303-310 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; ACTH ; Steroidogenesis ; Aldosterone escape phenomenon ; Stereology ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Short-term ACTH treatment provoked a decrease in volume of the lipid-droplet compartment in rat zona glomerulosa cells, and a rise in plasma and intracellular concentrations of corticosterone and aldosterone. It enhanced activities of 3β-hydroxysteroid dehydrogenase (3βHSD), 11β-hydroxylase (11βOH) and 18-hydroxylase (18OH). Long-term ACTH administration produced a hypertrophy of the zona glomerulosa and its parenchymal cells, a result of the increase in volume of the smooth endoplasmic reticulum and the mitochondrial compartment. The surface area per cell of mitochondrial inner membranes increased; the tubular cristae were transformed into a homogeneous population of vesicles. The plasma and intracellular concentrations of corticosterone further increased, whereas those of aldosterone fell below basal levels (the “aldosterone-escape” phenomenon). The activities of 3βHSD and 11βOH were enhanced, that of 180H decreased. Therefore, ACTH stimulates zona glomerulosa growth and transforms parenchymal elements into zona fasciculata celltypes. Cyanoketone nullified acute ACTH effects on plasma and intracellular concentrations of corticosterone and aldosterone, but did not affect the activities of 11βOH and 18OH. Chronic ACTH treatment produced similar results, although 18OH activity was not suppressed. The mechanism underlying the “aldosterone-escape” phenomenon may thus involve a rise in the intracellular concentration of corticosterone, caused by the enhanced synthesis and activation of 3βHSD and 11βOH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251044
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  • 9
    Electronic Resource
    Electronic Resource
    Effects of a prolonged treatment with aminoglutethimide on the zona fasciculata of rat adrenal cortex: A morphometric investigation (1987)
    Springer
    Cell & tissue research 248 (1987), S. 519-525 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Aminoglutethimide ; Corticosterone ; Morphometry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of a 7-day administration of aminoglutethimide (AG) on the adrenal zona fasciculata were examined in “normal” and dexamethasone/ACTH-treated rats. There was a 70–74% decrease in the concentration of corticosterone in blood, but no conspicuous qualitative changes suggesting cell degeneration occurred. Morphometry showed that AG induced a significant hypertrophy of the zona fasciculata and its parenchymal cells only in “normal” animals, which was due to an increase in the volume of the mitochondrial compartment and to proliferation of the smooth endoplasmic reticulum. This response to AG was considered to be non-specific and mediated by the enhanced secretion of ACTH following the decrease in the blood level of corticosterone. AG administration significantly increased the volume of the lipid-droplet compartment and the number of intramitochondrial lipid-like inclusions in both groups of animals. These changes were interpreted as the morphological counterpart of the AG-induced block of cholesterol utilization in steroid synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216478
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  • 10
    Electronic Resource
    Electronic Resource
    Sex differences in adrenocortical structure and function (1986)
    Springer
    Cell & tissue research 244 (1986), S. 141-145 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Sexual dimorphism ; Gonadectomy ; Stereology ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The cytological aspects of sexual dimorphism in the rat adrenal cortex and its relationship to the gonads have been investigated. The adrenal glands of mature female rats were heavier than those of males, and morphometry showed that this was almost exclusively due to conspicuous differences in the volume of cells of the zona fasciculata (ZF) and zona reticularis (ZR). Stereology demonstrated that the volume of the mitochondrial and lipid droplet compartments, as well as the surface area per cell of mitochondrial cristae and smooth endoplasmic reticulum tubules, were markedly higher in the ZF and ZR cells of female animals. Orchiectomy increased and ovariectomy decreased the adrenal weight, by eliciting hypertrophy and atrophy, respectively, of ZF and ZR cells; these effects of gonadectomy were reversed by the appropriate gonadal hormone replacement. It is suggested that the sexual dimorphism of the rat adrenal cortex may depend upon the inhibitory action of testosterone and the stimulatory effect of estradiol on the hypothalamo-hypophyseal-adrenal axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218391
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