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  • 1
    Monograph available for loan
    Monograph available for loan
    Struktur und Strukturumbauten der Chromosomen vielzelliger Organismen : [Vortrag in der wissenschaftlichen Sitzung des Plenums der Akademie am 14. Juni 1979] (1979)
    Berlin : Akad.-Verl.
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    Call number: MOP Per 672/A(1979,20)
    In: Sitzungsberichte der Akademie der Wissenschaften der DDR : N, Mathematik, Naturwissenschaften, Technik
    Type of Medium: Monograph available for loan
    Pages: 40 S. : Ill., graph. Darst.
    Series Statement: Sitzungsberichte der Akademie der Wissenschaften der DDR : N, Mathematik, Naturwissenschaften, Technik 1979,20
    Location: MOP - must be ordered
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    Chemical Induction of Heat-reversible ‘Potential Lesions’ in Vicia faba Chromosome (1965)
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 741-742 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 summarizes some of our results for recovery times (24 C) of 18, 24 and 30 h. Aberrations in TEM-treated cells become induced during interphase; they are preferentially localized in heterochromatin and they are exclusively on chromatid basis; the agent shows 'delayed effects13. The influence ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/206741a0
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction of Chromatid Breaks induced by Three Different Radiomimetic Compounds (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 1014-1015 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1. PRESENCE ( + ) OR ABSENCE (-) OF INTERACTION OF CHROMATID BREAKS INDUCED BY DIFFERENT AGENTS IN Vicia faba Root TIP MERISTEMS Agents used for treatment Interaction Kefs. X-rays and KCN + 1, 2 X-rays and 0-propiolactone + 1, 2 X-rays and 8-ethoxycaflfeine + 1, 2 X-rays ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1991014a0
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  • 4
    Electronic Resource
    Electronic Resource
    New Karyotypes of Vicia faba L. (1971)
    Springer
    Chromosoma 35 (1971), S. 1-8 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Five new karyotypes of V. faba are presented and the types and positions of the structural changes combined in the construction of these new karyotypes are described. All their chromosomes are easily distinguishable by morphological criteria. These new chromosome complements are presently used to study the inter- and intrachromosomal distribution of induced chromatid aberrations and related problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344679
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  • 5
    Electronic Resource
    Electronic Resource
    Distribution of heterochromatin in a reconstructed karyotype of Vicia faba as identified by banding- and DNA-late replication patterns (1978)
    Springer
    Chromosoma 69 (1978), S. 193-209 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract 1) The distribution pattern of heterochromatin characterized by Giemsa-banding, Quinacrine-banding and DNA-late replication has been studied in a reconstructed karyotype of Vicia faba with all chromosome pairs interdistinguishable. 2) By means of two Giemsa-banding methods both an interstitial and a centromeric Giemsa-banding pattern are described. The former one comprehends 14 “marker” and 18 “additional” bands of lower but characteristic visualization frequencies. The centromeric Giemsa-banding pattern consists of 7 bands, located in the centromeric and in the secondary constrictions of the metaphase chromosomes. Chromosomes with banding patterns intermediate between the interstitial and the centromeric Giemsa-banding have also been observed. 3) Quinacrine-banding revealed 10–12 brightly fluorescent bands and 1–2 regions of dim fluorescence. Most Q-bands occupy chromosomal positions also characterized by interstitial Giemsa bands. 4) The DNA-late replication pattern, analyzed both by autoradiography and by FPG-technique, revealed 9 late replicating chromosome regions; all of these correspond positionally to the sites of interstitial Giemsa bands. 5) The results are discussed with respect to (a) the relationships between the banding- and the DNA-late replication pattern; (b) banding and heterochromatin characteristics; (c) the correlations between the distribution of chromatid aberrations and special types of heterochromatin. — The patterns of heterochromatin distribution found are in basic conformity with the corresponding patterns reported for the standard karyotype of Vicia faba. The heterochromatin type characterized by both Giemsabanding and late replication is characteristic of all those chromosome regions which after mutagen treatments show up as aberration hot spots. Positional correlations between interstitial Giemsa marker bands and chemically induced isochromatid breaks are indicative of preferential aberration clustering in heterochromatin/euchromatin junctions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00329918
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  • 6
    Electronic Resource
    Electronic Resource
    Sister chromatid exchanges and heterochromatin (1981)
    Springer
    Human genetics 〈Berlin〉 57 (1981), S. 119-130 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The inter- and intrachromosomal distribution patterns of SCEs obtained with or without mutagen treatment are reviewed and compared, with each other as to their relation to heterochromatin and with the distribution patterns of chromatid aberrations that occurred either “spontaneously” in chromosomes of repair-defective human syndromes or after treatment with the mutagens (BrdU, ethylalcohol, DMBA, TMBA, maleic hydrazide, MMS, MMC). The conclusions are: No general rule is detectable for nonrandom involvement of heterochromatin in spontaneous SCEs. Mutagen-induced SCEs show the same or very similar distribution patterns as the spontaneous ones and are in no case as preferentially located as chromatid aberrations (which involve mainly the junctions between eu- and heterochromatin or other special regions). Therefore, a specific mutagen sensitivity of heterochromatincontaining chromosome regions as observed for chromatid aberrations does not exist (or is less pronounced) for SCEs. This supports the inference that different mechanisms underlie the origins of the two phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282006
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  • 7
    Electronic Resource
    Electronic Resource
    The Giemsa banding patterns of the standard and four reconstructed karyotypes of Vicia faba (1973)
    Springer
    Chromosoma 43 (1973), S. 409-422 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Giemsa banding patterns of the standard karyotype of Vicia faba and of four new karyotypes with easily interdistinguishable chromosomes due to interchanges and inversions are described and compared with the data of other authors on preferential Giemsa staining in Vicia faba. All karyotypes contain 14 easily reproducible marker bands which characterize chromosome segments known to be heterochromatic. It is shown that the preferential Giemsa staining of chromosome regions is a valuable tool for the localization of translocation and inversion points in the chromosomes of the reconstructed Vicia karyotypes. A close correlation exists between banding patterns, segment extension by incorporation into chromosomal DNA of azacytidine and mutagen-specific clustering of induced chromatid aberrations in the new karyotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406747
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  • 8
    Electronic Resource
    Electronic Resource
    Das Zentralinstitut für Genetik und Kulturpflanzenforschung Gatersleben der AdW der DDR im Zeitraum 1969–1983 — Versuch einer Rückschau auf Forschungsziele und ausgewählte Forschungsleistungen (1985)
    Springer
    Genetic resources and crop evolution 33 (1985), S. 19-31 
    Details
    ISSN: 1573-5109
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary A survey is given with respect to the development of the institute during the time period encompassing the years 1969–1983. Changes of the institute's structure and research topics as well as the main results of research are summarized. For references the reader should consult the lists of publications in the appropriate volumes of “Kulturpflanze” (volumes XVIII-XXXII).
    Abstract: Краткое содержание Дается обзор развития Центрального института за период времени 1969–1983 гг. Отмечаются изменения структуры института и его очередных заданий; излагаутся важнейшие результаты научно-исследовате ляской работы. Списки опубликованных работ института приведены в томах 18–32 журнала «Культурпфланце».
    Notes: Zusammenfassung Es wird ein Überblick über die Entwicklung des Zentralinstitutes im Zeitraum 1969–1983 gegeben. Änderungen der Institutsstruktur und Aufgabenstellung werden umrissen und wesentliche Ergebnisse der Forschungsarbeit dargestellt. Publikationslisten sind in den Bänden XVIII-XXXII der „Kulturpflanze“ enthalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01982855
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  • 9
    Electronic Resource
    Electronic Resource
    Über den Einfluß von Acridinfarbstoffen auf die Induktion von Chromatidenaberrationen durch Radiomimetica (1963)
    Springer
    Genetic resources and crop evolution 11 (1963), S. 403-415 
    Details
    ISSN: 1573-5109
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary Pretreatment of main root meristems ofVicia faba with acridine orange is sensitizing against the radiomimetic effectivity of nitrogen mustard and nitrogen oxide mustard. This is manifested by an increased percentage of metaphases with chromatid aberrations and a higher number of aberrations per damaged cell. Similar effects are found when pretreatment is done with trypaflavine instead of acridine orange, but acridine yellow and methyleneblue are unable to potentiate the mustard activity. The amount of sensitization is dependent on the dye-concentration used and on the duration of the pretreatment. Since sensitization is independent of light being present or not the effect is not connected with the photodynamic activity of the dyes. When triethylenemelamine or ethylalcohol are used for the induction of aberrations in place of the mustards, acridine orange is unable to give sensitization effects. The mechanism of sensitization is unknown up to now.
    Abstract: Краткое содержание Предварительная обработка меристемы главного корняVicia faba L. акридиновым оранжевым в темноте приводит к эффекту сенсибилизации в отношениии радиомиметического действия иприта и „митомена“. Эффект выражается в том, что процент метафаз с хроматидными аберрациями и число аберраций на поражённую клетку существенно возрастают. Подобные эффекты можно получить, если вместо акридинового оранжевого применять трипофлавин; однако акридиновый жёлтый и метиленовая синька оказались неэффективными. Степень повышения чувствительности зависит от концентрации красителя и от продолжительности воздействия. Так как эффект сенсибилизации не зависит от действия света, то вероятно он не связан и с фотодинамической активностью воздействующих красителей. Если для индукции аберраций вместо ипритов применять триэтиленмеламин или ¶rt;тиловый спирт, то предварительная обработка акридиновым оранжевым не влечёт за собой повышения чувствительности. механизм действия, лежащий в основе сенсибилизации ещё не известен.
    Notes: Zusammenfassung Vorbehandlung vonVicia faba Hauptwurzelmeristemen mit Acridinorange im Dunkeln führt zu einem Sensibilisierungseffekt gegenüber der radiomimetischen Wirkung von Stickstofflost und Stickstoffoxydlost, der sich darin ausdrückt, daß der prozentuale Anteil von Metaphasen mit Chromatidenaberrationen und die Anzahl der Aberrationen pro geschädigte Zelle signifikant erhöht werden. Ähnliche Effekte lassen sich erzielen, wenn anstelle von Acridinorange Trypaflavin zur Vorbehandlung verwendet wird, während sich Acridingelb und Methylenblau unwirksam erwiesen. Das Sensibilisierungsausmaß ist von der zur Einwirkung kommenden Farbstoffkonzentration und von der Einwirkungsdauer abhängig. Da der Sensibilisierungseffekt nicht an die Gegenwart von Licht gebunden ist, dürfte er nicht mit der photodynamischen Aktivität der wirksamen Farbstoffe in Verbindung stehen. Werden anstelle der Stickstoffloste Triäthylenmelamin bzw. Äthylalkohol zur Aberrationsinduktion verwendet, führt Acridinorange-Vorbehandlung zu keinem Sensibilisierungeffekt. Der der Sensibilisierung zugrunde liegende Wirkungsmechanismus ist noch unbekannt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136124
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  • 10
    Electronic Resource
    Electronic Resource
    Die Auslösung von Chromosomenaberrationen beiVicia faba durch chemische Agenzien (1962)
    Springer
    Genetic resources and crop evolution 10 (1962), S. 212-292 
    Details
    ISSN: 1573-5109
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary This paper is to give a survey of the work on the induction of chromosome aberrations by chemicals inVicia faba. Firstly some data characterizing object and methods are given (p. 213). In the second part it is tried to give a list as complete as possible of all chemicals tested for radiomimetic activity inVicia faba independent of their being effective or ineffective (p. 219). Published data are supplied by unpublished ones generously given by Drs. A. Loveless (London), B. A. Kihlman (Uppsala), N. S. Cohn (Athens, Ohio) and D. Davidson (St. Andrews, Scotland). The last part of the paper is concerned with the effects of combined treatment ofVicia faba with different agents (p. 256), with the distribution of aberrations between and within chromosomes (p. 259), with biochemical factors tested for influences on the radiomimetic activity of various compounds (p. 265) and with data and problems of the mode of action of some radiomimetic substances (p. 272).
    Abstract: Краткое содержание Дается обзор работ по индукции хромосомных перестроек химическими соединениями уVicia faba L. Сначала приводятся некоторые данные для характеристики объекта исследования и применяемых методов (стр. 213). Во второй части авторы пытаются дать возможно более полный список химических веществ, которые были испробованы на их способность вызывать уV. faba хромосомные мутации. Приводимый здесь материал, благодаря коллегиальной помощи А. Лавлеса (Лондон), Б. А. Кильмана (Упсала), Н. С. Кона (Этенс, Огайо) и Д. Дэвидсона (Ст. Андруз, Щотландия), мог быть значительно пополнен неопубликованными данными. В последней части работы даются сведения о комбинированном действии различных веществ (стр. 256), о распределеннии перестроек между хромосомами и внутри хромосом (стр. 259), о биохимических факторах, влияющих на индукцию аберраций (стр. 265) и о некоторых проблемах механизма действия радиомиметических веществ (стр. 272).
    Notes: Zusammenfassung Diese Arbeit soll einen Überblick über die Induktion von Chromosomenaberrationen durch chemische Agenzien beiVicia faba geben. Zuerst werden einige Angaben zur Charakterisierung des Untersuchungsobjektes und der eingesetzten Methoden gemacht (S. 160). Im zweiten Teil wird der Versuch unternommen, eine möglichst vollständige Übersicht über sämtliche chemische Substanzen zu geben, die beiVicia faba auf ihr Vermögen, Chromosomenmutationen zu induzieren, überprüft worden sind. Die publizierten Befunde konnten durch das Entgegenkommen von A. Loveless (London), B. A. Kihlman (Uppsala), N. S. Cohn (Athens, Ohio) und D. Davidson (St. Andrews, Schottland) durch bisher unveröffentlichtes Material ergänzt werden. Im letzten Teil der Arbeit werden Angaben über kombinierte Einwirkung verschiedener Agenzien (S. 167), über die inter- und intrachromosomale Aberrationsverteilung (S. 170), über biochemische, die Aberrationsauslösung beeinflussende Faktoren (S. 174) und über einige Befunde und Probleme im Zusammenhang mit dem Wirkungsmechanismus der Radiomimetika gemacht (S. 181).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02095443
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