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  • 1
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    Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration (2020)
    Cell Press
    Details
    Publication Date: 2020-11-01
    Print ISSN: 0092-8674
    Electronic ISSN: 1097-4172
    Topics: Biology , Medicine
    Published by Cell Press
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    PAPER CURRENT
  • 2
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    Kennedy Space Center Fixation Tube (KFT) (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Experiments performed on the International Space Station (ISS) frequently require the experimental organisms to be preserved until they can be returned to earth for analysis in the appropriate laboratory facility. The Kennedy Fixation Tube (KFT) was developed to allow astronauts to apply fixative, chemical compounds that are often toxic, to biological samples without the use of a glovebox while maintaining three levels of containment (Fig. 1). KFTs have been used over 200 times on-orbit with no leaks of chemical fixative. The KFT is composed of the following elements: a polycarbonate main tube where the fixative is loaded preflight, the sample tube where the plant or other biological specimens is placed during operations, the expansion plug, actuator, and base plug that provides fixative containment (Fig. 2). The main tube is pre-filled with 25 mL of fixative solution prior to flight. When actuated, the specimen contained within the sample tube is immersed with approximately 22 mL (+/- 2 mL) of the fixative solution. The KFT has been demonstrated to maintain its containment at ambient temperatures, 4degC refrigeration and -100 C freezing conditions.
    Keywords: Chemistry and Materials (General)
    Type: SP-2015-07-294-KSC , KSC-E-DAA-TN30924 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Advanced Plant Habitat (APH) (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Advanced Plant Habitat (APH) hardware will be a large growth volume plant habitat, capable of hosting multigenerational studies, in which environmental variables (e.g., temperature, relative humidity, carbon dioxide level light intensity and spectral quality) can be tracked and controlled in support of whole plant physiological testing and Bio-regenerative Life Support System investigations.
    Keywords: Man/System Technology and Life Support
    Type: SP-2015-07-289-KSC , KSC-E-DAA-TN30973 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Light Microscopy Module (LMM)-Emulator (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Light Microscopy Module (LMM) is a microscope facility developed at Glenn Research Center (GRC) that provides researchers with powerful imaging capability onboard the International Space Station (ISS). LMM has the ability to have its hardware recongured on-orbit to accommodate a wide variety of investigations, with the capability of remotely acquiring and downloading digital images across multiple levels of magnication.
    Keywords: Instrumentation and Photography
    Type: SP-2015-11-437-KSC , KSC-E-DAA-TN30969 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
    Format: application/pdf
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  • 5
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    Microgravity Simulation Facility (MSF) (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Microgravity Simulator Facility (MSF) at Kennedy Space Center (KSC) was established to support visiting scientists for short duration studies utilizing a variety of microgravity simulator devices that negate the directional influence of the "g" vector (providing simulated conditions of micro or partial gravity). KSC gravity simulators can be accommodated within controlled environment chambers allowing investigators to customize and monitor environmental conditions such as temperature, humidity, CO2, and light exposure.
    Keywords: Ground Support Systems and Facilities (Space)
    Type: SP-2015-11-434-KSC , KSC-E-DAA-TN30972 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
    Format: application/pdf
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  • 6
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    The Use of Microgravity Simulators for Space Research (2016)
    In:  CASI
    Details
    Publication Date: 2019-08-13
    Description: The spaceflight environment is known to influence biological processes ranging from stimulation of cellular metabolism to possible impacts on cellular damage repair, suppression of immune functions, and bone loss in astronauts. Microgravity is one of the most significant stress factors experienced by living organisms during spaceflight, and therefore, understanding cellular responses to altered gravity at the physiological and molecular level is critical for expanding our knowledge of life in space. Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogues have been widely used in space biology ground studies. Even though simulated microgravity conditions have produced some, but not all of the biological effects observed in the true microgravity environment, they provide test beds that are effective, affordable, and readily available to facilitate microgravity research. A Micro-g Simulator Center is being developed at Kennedy Space Center (KSC) to offer a variety of microgravity simulators and platforms for Space Biology investigators. Assistance will be provided by both KSC and external experts in molecular biology, microgravity simulation, and engineering. Comparisons between the physical differences in microgravity simulators, examples of experiments using the simulators, and scientific questions regarding the use of microgravity simulators will be discussed.
    Keywords: Life Sciences (General); Exobiology
    Type: KSC-E-DAA-TN29429 , The International Space Station Research and Development Conference; Jul 12, 2016 - Jul 14, 2016; San Diego, CA; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 7
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    FASTRACK (TM): Parabolic and Suborbital Experiment Support Facility (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: FASTRACK was developed by NASA Kennedy Space Center and Space Florida to provide capabilities to conduct frequent, affordable, and responsive flight opportunities for reduced gravity experiments, technology development, and hardware testing on suborbital vehicles and parabolic flights.
    Keywords: Research and Support Facilities (Air)
    Type: SP-2016-03-086-KSC , KSC-E-DAA-TN30966 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
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  • 8
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    BRIC-100VC Biological Research in Canisters (BRIC)-100VC (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Biological Research in Canisters (BRIC) is an anodized-aluminum cylinder used to provide passive stowage for investigations of the effects of space flight on small specimens. The BRIC 100 mm petri dish vacuum containment unit (BRIC-100VC) has supported Dugesia japonica (flatworm) within spring under normal atmospheric conditions for 29 days in space and Hemerocallis lilioasphodelus L. (daylily) somatic embryo development within a 5% CO2 gaseous environment for 4.5 months in space. BRIC-100VC is a completely sealed, anodized-aluminum cylinder (Fig. 1) providing containment and structural support of the experimental specimens. The top and bottom lids of the canister include rapid disconnect valves for filling the canister with selected gases. These specialized valves allow for specific atmospheric containment within the canister, providing a gaseous environment defined by the investigator. Additionally, the top lid has been designed with a toggle latch and O-ring assembly allowing for prompt sealing and removal of the lid. The outside dimensions of the BRIC-100VC canisters are 16.0 cm (height) x 11.4 cm (outside diameter). The lower portion of the canister has been equipped with sufficient storage space for passive temperature and relative humidity data loggers. The BRIC- 100VC canister has been optimized to accommodate standard 100 mm laboratory petri dishes or 50 mL conical tubes. Depending on storage orientation, up to 6 or 9 canisters have been flown within an International Space Station (ISS) stowage locker.
    Keywords: Life Sciences (General)
    Type: SP-2015-07-291-KSC , KSC-E-DAA-TN30962 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
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  • 9
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    The Use of Microgravity Simulators for Space Research (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The spaceflight environment is known to influence biological processes ranging from stimulation of cellular metabolism to possible impacts on cellular damage repair, suppression of immune functions, and bone loss in astronauts. Microgravity is one of the most significant stress factors experienced by living organisms during spaceflight, and therefore, understanding cellular responses to altered gravity at the physiological and molecular level is critical for expanding our knowledge of life in space. Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogues have been widely used in space biology ground studies. Even though simulated microgravity conditions have produced some, but not all of the biological effects observed in the true microgravity environment, they provide test beds that are effective, affordable, and readily available to facilitate microgravity research. Kennedy Space Center (KSC) provides ground microgravity simulator support to offer a variety of microgravity simulators and platforms for Space Biology investigators. Assistance will be provided by both KSC and external experts in molecular biology, microgravity simulation, and engineering. Comparisons between the physical differences in microgravity simulators, examples of experiments using the simulators, and scientific questions regarding the use of microgravity simulators will be discussed.
    Keywords: Exobiology; Life Sciences (General)
    Type: KSC-E-DAA-TN33670 , ASGSR Annual Conference; Oct 26, 2016 - Oct 29, 2016; Cleveland, OH; United States
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  • 10
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    BRIC-60: Biological Research in Canisters (BRIC)-60 (2016)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Biological Research in Canisters (BRIC) is an anodized-aluminum cylinder used to provide passive stowage for investigations evaluating the effects of space flight on small organisms. Specimens flown in the BRIC 60 mm petri dish (BRIC-60) hardware include Lycoperscion esculentum (tomato), Arabidopsis thaliana (thale cress), Glycine max (soybean) seedlings, Physarum polycephalum (slime mold) cells, Pothetria dispar (gypsy moth) eggs and Ceratodon purpureus (moss).
    Keywords: Life Sciences (General)
    Type: SP-2015-07-289-KSC , KSC-E-DAA-TN30950 , Space Symposium; Apr 11, 2016 - Apr 14, 2016; Colorado Springs, CO; United States
    Format: application/pdf
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