ISSN:
1432-0827
Keywords:
Key words: Bone densitometry — Anorexia nervosa — Quantitative ultrasound.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Abstract. In 20 patients (mean age 23 ± 5 years) with anorexia nervosa (AN), bone mass was evaluated by broadband ultrasound attenuation (BUA) of the calcaneus, peripheral quantitative computed tomography (pQCT) of the distal radius, and dual X-ray absorptiometry (DXA) of the lumbar spine and the hip. Compared with 20 age- and sex- matched healthy controls, patients with AN showed marked osteopenia at all measuring sites. Values of BUA (33.0 ± 9dB/MHz vs. 51.0 ± 5.7 dB/MHz; P 〈 0.0001) and of BMD of all regions of the hip (e.g., femoral neck: 0.71 ± 0.13 g/cm2 versus 0.89 ± 0.07 g/cm2; P 〈 0.001), lumbar spine (0.82 ± 0.15 g/cm2 versus 1.24 ± 0.06 g/cm2; P 〈 0.003) and total BMD of the peripheral radius (303.2 ± 75 g/cm3 versus 369.4 ± 53.2 g/cm3, P 〈 0.001) were significantly reduced. Calculating a Z-score we found the most prominent differences between AN and controls by BUA of the calcaneus (−3.2 ± 1.6), followed by DXA at the lumbar spine (−2.9 ± 2.2) and the hip (femoral neck −2.1 ± 1.7) and by pQCT at the distal radius (total BMD −1.2 ± 2.0). There were highly significant correlations between BUA of the calcaneus and BMD of the femoral neck (r = 0.78, P 〈 0.0001) and lumbar spine (r = 0.75, P 〈 0.0001) as well as between BMD values of the femoral neck and lumbar spine (r = 0.95; P 〈 0.0001). In addition, there were significant correlations (P 〈 0.001) between body mass index (BMI) and the three different measuring sites and between the duration of the disease and BUA (r = 0.5, P 〈 0.05). Our data suggest that BUA of the calcaneus is a valuable tool in the management of osteoporosis. Being a fast, radiation-free investigation method of good acceptance, it may be well suited for an assessment of the skeletal status in patients with AN.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002230010070
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