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  • 1
    Publication Date: 1983-01-01
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 10 (1972), S. 207-215 
    ISSN: 1432-0827
    Keywords: Bone ; Calcium ; Fluoride ; Diet ; Collagen ; Hexosamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Une fluorose squelettique est induite chez des lapins soumis à des régimes adéquates et faibles en calcium. Les lapins soumis à un régime pauvre en calcium sont plus sensibles à l'intoxication fluorée, ainsi que le démontre les exostoses et la rétention plus élvée de fluor du fémur. La matrice collagène de l'os et la synthèse de l'hexosamine, étudiée par l'incorporation de proline (U)14C dans le collagène et de glucose (1)14C dans l'hexosamine, ne semblent pas affecter par le fluor et par la concentration de calcium dans le régime des lapins.
    Abstract: Zusammenfassung Skelettfluorose wurde bei Kaninchen hervorgerufen, welche ausreichende und niedrige Calciumdiäten erhielten. Kaninchen mit einem niedrigen Calciumgehalt in der Nahrung entwickelten eine stärkere Fluoridintoxikation, was sich durch Exostosebildung und höhere Fluoridretention in den Femora zeigte. Die Synthese des Knochenmatirx-Collagens und der Hexosamine [untersucht mittels Einbau von Prolin (U)14C in Collagen und Glukose (1)14C in Hexosamin] wurde weder durch Fluorid noch durch den Calciumgehalt der Kaninchen-Nahrung beeinflußt.
    Notes: Abstract Skeletal fluorosis was induced in rabbits fed adequate and low calcium diets. Rabbits on a low calcium diet were found to suffer more from fluoride intoxication as evidenced by exostosis formation and higher retention of fluoride in the femora. Bone matrix collagen and hexosamine synthesis assessed by14C-proline (U) incorporation into collagen and14C-glucose (1) into hexosamine were found to be unaffected by the fluoride as well as by the level of calcium in the diets of rabbits.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 24 (1983), S. 255-259 
    ISSN: 1432-1041
    Keywords: levonorgestrel ; nutritional status ; combination pill ; pharmacokinetics ; indian women
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A low dose combination pill containing levonorgestrel 150 µg and ethynylestradiol 50 µg was administered orally to 13 women. Based on their anthropometric index they were classed as well-nourished (Group A) or undernourished (Group B). Plasma levels of levonorgestrel at various intervals after dosing were analysed by a specific radioimmunoassay and its pharmacokinetic parameters were computed. Peak plasma levels in both groups occurred within 2 h and the absorption half-lives were also similar. The decline in plasma levonorgestrel showed a tri-exponential decline in all Group A women, whereas it was biphasic in most of Group B. The π t1/2 was lower in Group A women and the α-phase was found to be negligible in Group B. A significant positive correlation between elimination half-life (β t1/2) and some of the anthropometric indices suggests a possible role of nutritional status in the metabolic handling of levonorgestrel.
    Type of Medium: Electronic Resource
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