ISSN:
1432-0827
Keywords:
Bone mineral content
;
Densitometry
;
Radiography
;
Cynomolgus monkeys
;
Aging
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Abstract A cross-sectional study by age was designed to evaluate and describe the bone mineral content (BMC, g) and density (BMD, g/cm2) in a population of female cynomolgus macaques (Macaca fascicularis). Dual-energy X-ray absorptiometry was used to measure, in segments L2-L4 of the lumbar spine, the BMC (BMCs), BMD (BMDs), length, and total-body BMC (BMCTB) in 171 female monkeys ranging in age between 3.7 and 22.0 years. The animals were divided into three age groups: (1) young (〈6.5 years, n=51); (2) adult (〉6.5 years and 〈10.5 years, n=63); and (3) mature (〉10.5 years, n=57). Young animals had a significantly lower (P〈0.05) body weight and shorter trunk length than adult or mature animals. Young animals also had significantly less (P〈0.05) BMCS, BMDS, and BMCTB than adult or mature animals, and had significantly shorter (P〈0.05) lumbar spine vertebral segments than the other two groups. Longitudinally, 63 animals had repeated lumbar spine scans to examine changes over time. Young animals showed a positive and significant change (P〈0.05) in BMCS and BMDS through time, whereas these parameters did not change in adult animals, and mature animals had a trend towards bone loss through time. Densitometric results suggested that peak bone mass in the lumbar spine was achieved by 9 years of age. Radiographic and dental criteria were developed to identify animals that had reached peak bone mass, and the combined radiographic and dental scoring system reliably identified animals 9 years and older. Female cynomolgus macaques 9 years old or older are recommended for investigations of bone remodeling and associated conditions, such as osteoporosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00301684
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