ISSN:
1432-0983
Keywords:
Regulation
;
Lactate utilization
;
Mitochondria
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary A strain dependent growth on lactate in the presence of antimycin A (AA) has been observed — the strain D261 can grow on lactate and AA, whereas in the strain K8/6C antimycin A prevents the utilization of lactate and the induction of LDH. Genetic analysis demonstrates that growth on lactate in the presence of AA segregates from D261 as a single nuclear factor which we indicate by ALG1 and alg1 in its dominant and recessive states. alg1 complements the gene(s) which give(s) rise to the same phenotype in K8/6C. The analysis of the regulation by lactate of LDH in the absence and presence of AA and in rho − cells shows that growth on lactate and antimycin A is not corretated with the induction by lactate of LDH.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433906
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