ISSN:
1420-9071
Keywords:
Cholecystokinin octapeptide
;
cholecystokinin antagonist (GE 410)
;
[3H]ACh release
;
ileac smooth muscle
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp-β-phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01940666
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