Publication Date:
2002-04-06
Description:
Successful repair after tissue injury and inflammation requires resolution of the inflammatory response and removal of extracellular matrix breakdown products. We have examined whether the cell-surface adhesion molecule and hyaluronan receptor CD44 plays a role in resolving lung inflammation. CD44-deficient mice succumb to unremitting inflammation following noninfectious lung injury, characterized by impaired clearance of apoptotic neutrophils, persistent accumulation of hyaluronan fragments at the site of tissue injury, and impaired activation of transforming growth factor-beta1. This phenotype was partially reversed by reconstitution with CD44+ cells, thus demonstrating a critical role for this receptor in resolving lung inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teder, Priit -- Vandivier, R William -- Jiang, Dianhua -- Liang, Jiurong -- Cohn, Lauren -- Pure, Ellen -- Henson, Peter M -- Noble, Paul W -- HL60539/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):155-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11935029" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD44/*physiology
;
Apoptosis
;
Bleomycin
;
Bone Marrow Transplantation
;
Bronchoalveolar Lavage Fluid/chemistry/cytology
;
Cell Count
;
Chemokines/genetics/metabolism
;
Chimera
;
Humans
;
Hyaluronic Acid/analysis/metabolism
;
Lung/immunology/metabolism/*pathology
;
Lung Diseases, Interstitial/*immunology/metabolism/*pathology
;
Macrophages, Alveolar/physiology
;
Mice
;
Mice, Inbred C57BL
;
Neutrophil Infiltration
;
Neutrophils
;
Phagocytosis
;
Phenotype
;
Pulmonary Alveoli/immunology/metabolism/pathology
;
RNA, Messenger/genetics/metabolism
;
Transforming Growth Factor beta/metabolism
;
Transforming Growth Factor beta1
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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