Publication Date:
1986-02-07
Description:
Rat optic and sciatic nerves were crushed, and 10 minutes to 3 days later nerve segments between the crushed site and the cell body were removed and assayed for posttranslational protein modification by amino acid addition. Protein modification was comparable in intact optic and sciatic nerves, but in sciatic nerves increased to 1.6 times control levels 10 minutes after crushing and reached a maximum of ten times control levels by 2 hours. In optic nerves activity was decreased throughout the time course studied. The results indicate that, in a nerve which is capable of regeneration (sciatic), protein modification by the addition of amino acids increases immediately after injury, but a nerve incapable of regeneration (optic) is incapable of activating the modification reaction. These findings may be important in understanding the reasons for the lack of a regenerative response after injury to central mammalian nerves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shyne-Athwal, S -- Riccio, R V -- Chakraborty, G -- Ingoglia, N A -- NS19148/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1986 Feb 7;231(4738):603-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3080804" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acids/*metabolism
;
Animals
;
Arginine/metabolism
;
Decapodiformes
;
Goldfish
;
Leucine/metabolism
;
Lysine/metabolism
;
Nerve Regeneration
;
Nerve Tissue Proteins/*metabolism
;
Optic Nerve/*metabolism/physiology
;
Optic Nerve Injuries
;
Rats
;
Sciatic Nerve/injuries/*metabolism/physiology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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