Publication Date:
1983-10-14
Description:
Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- McIsaac, R M -- Chen, L B -- CA22427/CA/NCI NIH HHS/ -- CA29793/CA/NCI NIH HHS/ -- CA33847/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):169-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623064" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carcinoma/*drug therapy
;
Carcinoma, Ehrlich Tumor/*drug therapy
;
Cell Line
;
Deoxyglucose/therapeutic use
;
Drug Synergism
;
Drug Therapy, Combination
;
Energy Metabolism/drug effects
;
Mice
;
Mitochondria/drug effects
;
Rhodamine 123
;
Rhodamines/*therapeutic use
;
Urinary Bladder Neoplasms/*drug therapy
;
Xanthenes/*therapeutic use
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
