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  • 1
    Publication Date: 2013-07-23
    Description: Although the gut microbiome influences numerous aspects of organismal fitness, its role in animal evolution and the origin of new species is largely unknown. Here we present evidence that beneficial bacterial communities in the guts of closely related species of the genus Nasonia form species-specific phylosymbiotic assemblages that cause lethality in interspecific hybrids. Bacterial constituents and abundance are irregular in hybrids relative to parental controls, and antibiotic curing of the gut bacteria significantly rescues hybrid survival. Moreover, feeding bacteria to germ-free hybrids reinstates lethality and recapitulates the expression of innate immune genes observed in conventionally reared hybrids. We conclude that in this animal complex, the gut microbiome and host genome represent a coadapted "hologenome" that breaks down during hybridization, promoting hybrid lethality and assisting speciation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brucker, Robert M -- Bordenstein, Seth R -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):667-9. doi: 10.1126/science.1240659. Epub 2013 Jul 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. bruckerm@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23868918" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*classification/genetics ; Chimera/microbiology/physiology ; Gastrointestinal Tract/*microbiology ; Germ-Free Life/genetics/*physiology ; Hymenoptera/genetics/*microbiology/*physiology ; Metagenome ; Phylogeny ; Species Specificity ; *Symbiosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2014-08-30
    Description: Chandler and Turelli postulate that intrinsic hybrid dysfunction underscores hybrid lethality in Nasonia. Although it is a suitable conception for examining hybrid incompatibilities, their account of the evidence is factually inaccurate and leaves out the evolutionary process for why lethality became conditional on nuclear-microbe interactions. Hybrid incompatibilities in the context of phylosymbiosis are resolved by hologenomic principles and exemplify this emerging postmodern synthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brucker, Robert M -- Bordenstein, Seth R -- New York, N.Y. -- Science. 2014 Aug 29;345(6200):1011. doi: 10.1126/science.1256708.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Rowland Institute at Harvard University, Cambridge, MA 02142, USA. bruckerm@gmail.com s.bordenstein@vanderbilt.edu. ; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA. Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA. bruckerm@gmail.com s.bordenstein@vanderbilt.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170145" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacteria/*classification ; Gastrointestinal Tract/*microbiology ; Germ-Free Life/*physiology ; Hymenoptera/*microbiology/*physiology ; *Symbiosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Location Call Number Expected Availability
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