Publication Date:
1980-06-27
Description:
The Pb2+ and Zn2+ ions are efficient catalysts for the polycytidylic acid-directed polymerization of an activated guanylic acid derivative, guanosine 5'-phosphorimidazolide. The products include oligomers of 30 to 40 units in length. The nucleotide residues are predominantly 2'-5' linked when Pb2+ is the catalyst, and predominantly 3'-5' linked in the presence of Zn2+. The significance of these results in the context of the prebiotic evolution of RNA polymerase is discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lohrmann, R -- Bridson, P K -- Orgel, L E -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1464-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6247762" target="_blank"〉PubMed〈/a〉
Keywords:
DNA-Directed RNA Polymerases
;
Guanine Nucleotides/*chemical synthesis
;
Guanosine Monophosphate/analogs & derivatives/*chemical synthesis
;
*Lead
;
Pancreas/enzymology
;
*Poly C
;
*Polyribonucleotides
;
Ribonucleases
;
Templates, Genetic
;
*Zinc
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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