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  • 1
    Monograph available for loan
    Monograph available for loan
    Cambridge : Cambridge University Press
    Call number: PIK M 531-01-0366
    Type of Medium: Monograph available for loan
    Pages: 564 p.
    Edition: 1. ed.
    ISBN: 0521642949
    Series Statement: Cambridge Studies in Adaptive Dynamics ;
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    Description / Table of Contents: This collection of 27 review and research papers provides an overview of the geodynamic concepts of channel flow and ductile extrusion in continental collision zones. The focal point tor this volume is the proposal that the middle or lower crust acts as a ductile, partially molten channel flowing out from beneath areas of over-thickened crust, such as the Tibetan plateau, towards the topographic surface at plateau margins. This controversial proposal explains many features related to the geodynamic evolution of the plateau and, for example, extrusion and exhumation of the crystalline core of the Himalayan mountain chain to the south. In this volume thermal-mechanical models for channel flow, extrusion and exhumation are presented, and geological and geophysical evidence both for and against the applicability of such models to the Himalayan-Tibetan Plateau system, as well as older continental collision zones such as the Hellenides, the Appalachians and the Canadian Cordillera, are discussed.
    Pages: Online-Ressource (X, 620 Seiten)
    ISBN: 9781862392090
    Language: English
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  • 3
    Description / Table of Contents: The world's mountain ranges are the clearest manifestations of long-term deformation of the continental crust. As such they have attracted geological investigations for centuries. Throughout this long history of research a few keynote publications stand out. One of the most important is the Geological Survey's 1907 Memoir on The Geological Structure of the North-West Highlands of Scotland. The Memoir summarized some of the Geological Survey's finest work, and outlined many of the principles of field-based structural and tectonic analysis that have subsequently guided generations of geologists working in other mountain belts, both ancient and modern. The thematic set of 32 papers in this Special Publication celebrate the 100th anniversary of the 1907 Memoir by placing the original findings in both historical and modern contexts, and juxtaposing them against present-day studies of deformation processes operating not only in the NW Highlands, but also in other mountain belts.
    Pages: Online-Ressource (VII, 872 Seiten)
    ISBN: 9781862393004
    Language: English
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Carbohydrate Research 42 (1975), S. 209-216 
    ISSN: 0008-6215
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2012-04-18
    Description: Hepatitis C virus (HCV) infects ∼2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt, the country with the highest HCV prevalence. An effective vaccine would help control this expanding global health burden. HCV is highly variable, and an effective vaccine should target conserved T- and B-cell epitopes of the virus. Conserved B-cell epitopes overlapping the CD81 receptor-binding site (CD81bs) on the E2 viral envelope glycoprotein have been reported previously and provide promising vaccine targets. In this study, we isolated 73 human mAbs recognizing five distinct antigenic regions on the virus envelope glycoprotein complex E1E2 from an HCV-immune phage-display antibody library by using an exhaustive-panning strategy. Many of these mAbs were broadly neutralizing. In particular, the mAb AR4A, recognizing a discontinuous epitope outside the CD81bs on the E1E2 complex, has an exceptionally broad neutralizing activity toward diverse HCV genotypes and protects against heterologous HCV challenge in a small animal model. The mAb panel will be useful for the design and development of vaccine candidates to elicit broadly neutralizing antibodies to HCV.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 6
    Publication Date: 2011-08-30
    Description: Iron minerals influence the environmental redox behaviour and mobility of metals including the long-lived radionuclide technetium. Technetium is highly mobile in its oxidized form pertechnetate (Tc(VII)[IMG]f1.gif" ALT="Formula" BORDER="0"〉), however, when it is reduced to Tc(IV) it immobilizes readily via precipitation or sorption. In low concentration tracer experiments, and in higher concentration XAS experiments, pertechnetate was added to samples of biogenic and abiotically synthesized Fe(II)-bearing minerals (bio-magnetite, bio-vivianite, bio-siderite and an abiotically precipitated Fe(II) gel). Each mineral scavenged different quantities of Tc(VII) from solution with essentially complete removal in Fe(II)-gel and bio-magnetite systems and with 84{+/-}4% removal onto bio-siderite and 68{+/-}5% removal onto bio-vivianite over 45 days. In select, higher concentration, Tc XAS experiments, XANES spectra showed reductive precipitation to Tc(IV) in all samples. Furthermore, EXAFS spectra for bio-siderite, bio-vivianite and Fe(II)-gel showed that Tc(IV) was present as short range ordered hydrous Tc(IV)O2-like phases in the minerals and for some systems suggested possible incorporation in an octahedral coordination environment. Low concentration reoxidation experiments with air-, and in the case of the Fe(II) gel, nitrate-oxidation of the Tc(IV)-labelled samples resulted in only partial remobilization of Tc. Upon exposure to air, the Tc bound to the Fe-minerals was resistant to oxidative remobilization with a maximum of [~]15% Tc remobilized in the bio-vivianite system after 45 days of air exposure. Nitrate mediated oxidation of Fe(II)-gel inoculated with a stable consortium of nitrate-reducing, Fe(II)-oxidizing bacteria showed only 3.8{+/-}0.4% remobilization of reduced Tc(IV), again highlighting the recalcitrance of Tc(IV) to oxidative remobilization in Fe-bearing systems. The resultant XANES spectra of the reoxidized minerals showed Tc(IV)-like spectra in the reoxidized Fe-phases. Overall, this study highlights the role that Fe-bearing biogenic mineral phases have in controlling reductive scavenging of Tc(VII) to hydrous TcO2-like phases onto a range of Fe(II)-bearing minerals. In addition, it suggests that on reoxidation of these phases, Fe-bound Tc(IV) may be octahedrally coordinated and is largely recalcitrant to reoxidation over medium-term timescales. This has implications when considering remediation approaches and in predictions of the long-term fate of Tc in the nuclear legacy.
    Print ISSN: 0026-461X
    Electronic ISSN: 1471-8022
    Topics: Geosciences
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  • 7
    Publication Date: 2016-05-26
    Description: Suppressing star formation in quiescent galaxies with supermassive black hole winds Nature 533, 7604 (2016). doi:10.1038/nature18006 Authors: Edmond Cheung, Kevin Bundy, Michele Cappellari, Sébastien Peirani, Wiphu Rujopakarn, Kyle Westfall, Renbin Yan, Matthew Bershady, Jenny E. Greene, Timothy M. Heckman, Niv Drory, David R. Law, Karen L. Masters, Daniel Thomas, David A. Wake, Anne-Marie Weijmans, Kate Rubin, Francesco Belfiore, Benedetta Vulcani, Yan-mei Chen, Kai Zhang, Joseph D. Gelfand, Dmitry Bizyaev, A. Roman-Lopes & Donald P. Schneider Quiescent galaxies with little or no ongoing star formation dominate the population of galaxies with masses above 2 × 1010 times that of the Sun; the number of quiescent galaxies has increased by a factor of about 25 over the past ten billion years (refs 1, 2, 3, 4). Once star formation has been shut down, perhaps during the quasar phase of rapid accretion onto a supermassive black hole, an unknown mechanism must remove or heat the gas that is subsequently accreted from either stellar mass loss or mergers and that would otherwise cool to form stars. Energy output from a black hole accreting at a low rate has been proposed, but observational evidence for this in the form of expanding hot gas shells is indirect and limited to radio galaxies at the centres of clusters, which are too rare to explain the vast majority of the quiescent population. Here we report bisymmetric emission features co-aligned with strong ionized-gas velocity gradients from which we infer the presence of centrally driven winds in typical quiescent galaxies that host low-luminosity active nuclei. These galaxies are surprisingly common, accounting for as much as ten per cent of the quiescent population with masses around 2 × 1010 times that of the Sun. In a prototypical example, we calculate that the energy input from the galaxy’s low-level active supermassive black hole is capable of driving the observed wind, which contains sufficient mechanical energy to heat ambient, cooler gas (also detected) and thereby suppress star formation.
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 8
    Publication Date: 2012-07-20
    Description: Although grand-design spiral galaxies are relatively common in the local Universe, only one has been spectroscopically confirmed to lie at redshift z 〉 2 (HDFX 28; z = 2.011); and it may prove to be a major merger that simply resembles a spiral in projection. The rarity of spirals has been explained as a result of disks being dynamically 'hot' at z 〉 2 (refs 2-5), which may instead favour the formation of commonly observed clumpy structures. Alternatively, current instrumentation may simply not be sensitive enough to detect spiral structures comparable to those in the modern Universe. At z 〈 2, the velocity dispersion of disks decreases, and spiral galaxies are more numerous by z approximately 1 (refs 7, 13-15). Here we report observations of the grand-design spiral galaxy Q2343-BX442 at z = 2.18. Spectroscopy of ionized gas shows that the disk is dynamically hot, implying an uncertain origin for the spiral structure. The kinematics of the galaxy are consistent with a thick disk undergoing a minor merger, which can drive the formation of short-lived spiral structure. A duty cycle of 〈100 Myr for such tidally induced spiral structure in a hot massive disk is consistent with its rarity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Law, David R -- Shapley, Alice E -- Steidel, Charles C -- Reddy, Naveen A -- Christensen, Charlotte R -- Erb, Dawn K -- England -- Nature. 2012 Jul 18;487(7407):338-40. doi: 10.1038/nature11256.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dunlap Institute for Astronomy & Astrophysics, University of Toronto, 50 St George Street, Toronto M5S 3H4, Ontario, Canada. drlaw@di.utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22810697" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2008-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Browman, Howard I -- Law, Richard -- Marshall, C Tara -- New York, N.Y. -- Science. 2008 Apr 4;320(5872):47-50; author reply 47-50. doi: 10.1126/science.320.5872.47b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18388275" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Ecosystem ; *Fisheries ; *Fishes ; Phenotype
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2012-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia, S M -- Kolding, J -- Rice, J -- Rochet, M-J -- Zhou, S -- Arimoto, T -- Beyer, J E -- Borges, L -- Bundy, A -- Dunn, D -- Fulton, E A -- Hall, M -- Heino, M -- Law, R -- Makino, M -- Rijnsdorp, A D -- Simard, F -- Smith, A D M -- New York, N.Y. -- Science. 2012 Mar 2;335(6072):1045-7. doi: 10.1126/science.1214594.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Commission on Ecosystem Management, International Union for Conservation of Nature (IUCN-CEM), Fisheries Expert Group, Brussels, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383833" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biodiversity ; Biomass ; Body Size ; *Conservation of Natural Resources ; *Ecosystem ; *Fisheries ; *Fishes ; Models, Biological ; Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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