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  • 1
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    A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2 (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-07
    Description: The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) raises the question of how a particular receptor selectively regulates specific targets. We provide insight into this question by identifying a prototypical macromolecular signaling complex. The beta(2) adrenergic receptor was found to be directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(v)1.2. This complex also contained a G protein, an adenylyl cyclase, cyclic adenosine monophosphate-dependent protein kinase, and the counterbalancing phosphatase PP2A. Our electrophysiological recordings from hippocampal neurons demonstrate highly localized signal transduction from the receptor to the channel. The assembly of this signaling complex provides a mechanism that ensures specific and rapid signaling by a G protein-coupled receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davare, M A -- Avdonin, V -- Hall, D D -- Peden, E M -- Burette, A -- Weinberg, R J -- Horne, M C -- Hoshi, T -- Hell, J W -- AG00213/AG/NIA NIH HHS/ -- AG17502/AG/NIA NIH HHS/ -- GM08688/GM/NIGMS NIH HHS/ -- GM56900/GM/NIGMS NIH HHS/ -- HL61645/HL/NHLBI NIH HHS/ -- NS35563/NS/NINDS NIH HHS/ -- NS39444/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):98-101.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, University of Wisconsin, Madison, WI 53706, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441182" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Adrenergic beta-2 Receptor Agonists ; Albuterol/pharmacology ; Animals ; Calcium Channels, L-Type/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Electric Conductivity ; Fluorescent Antibody Technique ; Heterotrimeric GTP-Binding Proteins/metabolism ; Humans ; Isoproterenol/pharmacology ; Kinetics ; Macromolecular Substances ; Neurons/cytology/drug effects/enzymology/metabolism ; Phosphoprotein Phosphatases/metabolism ; Precipitin Tests ; Prosencephalon/cytology/metabolism ; Protein Binding ; Pyramidal Cells/cytology/drug effects/enzymology/metabolism ; Rats ; Receptors, Adrenergic, beta-2/genetics/*metabolism ; *Signal Transduction ; Substrate Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Convection in a partially molten metasedimentary crust? Insights from the El Oro complex (Ecuador) (2015)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2015-12-24
    Description: The El Oro complex, southwestern Ecuador, is a tilted section of the metasedimentary Ecuadorian forearc, which was partially molten during Triassic time due to gabbroic magma emplacement. Pressure and maximum temperature estimates show that the metamorphic gradient during anatexis was 45 °C/km in the upper crust and 10 °C/km in the 7–8 km garnet-bearing migmatitic lower crust, controlled by biotite-breakdown melting reactions. Our petrological and geochemical studies indicate that melts produced during biotite-breakdown (5–15 vol%) were trapped and pervasively distributed in the garnet-bearing migmatite. Based on these results we carried out one-dimensional thermal modeling to characterize the heat transfer processes that led to the establishment of such a low thermal gradient during partial melting. Our results show that neither diffusive nor upward melt transfer models account for the low metamorphic gradient in the garnet-bearing migmatite. We demonstrate that in the El Oro complex, convection of the garnet-bearing migmatitic layer is the most likely heat transfer process that explains all the petrological, geochemical, and metamorphic data.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 3
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    Multiple intrusions and remelting-remobilization events in a magmatic arc: The St. Peter Suite, South Australia (2014)
    Geological Society of America (GSA)
    Details
    Publication Date: 2014-08-29
    Description: Granitoids with juvenile signatures are common in arc environments and contribute to growth of the continental crust. Thermo-mechanical models of arcs suggest that intermittent intrusion of magma batches leads to magma hybridization, remelting, and remobilization of earlier intrusive rocks driven by fluctuations in temperature and water fluxing. While there are numerous examples in the literature of multiple intrusions and magma hybridization, field examples of remelting and remobilization of earlier intrusive rocks within an arc are rare. Here, we investigate the evolution of magmatic rocks of the Paleoproterozoic St. Peter Suite, emplaced along the SW margin of the Gawler craton, South Australia, a typical calc-alkaline arc suite. Magmatic rocks recording multiple intrusions and multiple magma interactions have undergone in situ remelting and remobilization forming migmatites. Laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) U-Pb zircon dating yielded crystallization ages of 1647 ± 12 Ma for a tonalitic gneiss representing the oldest intrusive suite, and 1604 ± 12 Ma for a leucogranite representing the youngest intrusive suite. Both these suites developed synmagmatic foliation and magmatic banding defined by broadly parallel dikes, elongated enclaves, and schlieren. The rock suites record two deformation events associated with anatexis. The first event, D 1 , was responsible for a dominant approximately E-W–striking foliation (S 1 ) parallel to magmatic foliation, and associated with a dominantly sinistral shearing that affected the older suite. This deformation was associated with the first anatectic event, as demonstrated by the association between leucosomes and structures. The second deformation event, D 2 , affected both suites and was characterized by isolated F 2 folds and shear planes filled with leucosomes subparallel to axial planar foliation. Leucosomes interconnected and gave rise to magma extraction channels tens of meters long. Sensitive high-resolution ion microprobe (SHRIMP) U-Pb titanite dating of a late leucosome sample, collected from within the older magmatic suite, yielded an age of 1605 ± 7 Ma, coinciding with the crystallization age of the younger suite rather than postdating it, as expected. We interpret these results to indicate that crystallization of the younger suite and the second anatectic event occurred in the time encompassed by the error of these young ages. Leucosomes from both anatectic phases lack anhydrous peritectic phases and are interpreted to represent low-temperature anatexis resulting from water fluxing. Combined, these results suggest that a protracted and complex intrusive history can be made significantly more complex by anatexis, giving rise to evolved magmas after older ones, erasing earlier intrusive relationships, and establishing new ones. Rocks of the St. Peter Suite record many of the key processes expected in arcs, including the prediction that early intrusive arc rocks remelt to form younger and more fractionated magmas.
    Print ISSN: 0016-7606
    Electronic ISSN: 1943-2674
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 4
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    Recycling of metal-fertilized lower continental crust: Origin of non-arc Au-rich porphyry deposits at cratonic edges (2017)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2017-05-13
    Description: Recent studies argue that subduction-modified, Cu-fertilized lithosphere controls the formation of porphyry Cu deposits in orogenic belts. However, it is unclear if and how this fertilization process operates at cratonic edges, where numerous large non-arc Au-rich deposits form. Here we report data from lower crustal amphibolite and garnet amphibolite xenoliths hosted by Cenozoic stocks that are genetically related to the Beiya Au-rich porphyry deposits along the western margin of the Yangtze craton, China. These xenoliths are thought to represent cumulates or residuals of Neoproterozoic arc magmas ponding at the base of arc at the edge of the craton that subsequently underwent high-pressure metamorphism ca. 738 Ma. The amphibolite xenoliths are enriched in Cu (383–445 ppm) and Au (7–12 ppb), and a few garnet amphibolite xenoliths contain higher Au (6–16 ppb) with higher Au/Cu ratios (2 x 10 –4 to 8 x 10 –4 ) than normal continental crust. These data suggest that metal fertilization of the base of an old arc at the edge of the craton occurred in the Neoproterozoic via subduction modification, and has since been preserved. The whole-rock geochemical and zircon Hf isotopic data indicate that melting of the Neoproterozoic Cu-Au–fertilized low-crustal cumulates at 40–30 Ma provided the metal endowment for the Au-rich porphyry system at the cratonic edge. We therefore suggest that the reactivated cratonic edges, triggered by upwelling of asthenosphere, have the potential to host significant Au ore-forming systems, especially non-arc Au-rich porphyry deposits.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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