Publication Date:
2000-12-16
Description:
The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in cell-based assays. Purification and analysis of the factor by mass spectrometry revealed that it is docosahexaenoic acid (DHA), a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain. Previous work has shown that DHA is essential for brain maturation, and deficiency of DHA in both rodents and humans leads to impaired spatial learning and other abnormalities. These data suggest that DHA may influence neural function through activation of an RXR signaling pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Urquiza, A M -- Liu, S -- Sjoberg, M -- Zetterstrom, R H -- Griffiths, W -- Sjovall, J -- Perlmann, T -- New York, N.Y. -- Science. 2000 Dec 15;290(5499):2140-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S-171 77 Stockholm, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11118147" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Biological Assay
;
Brain/growth & development/metabolism
;
*Brain Chemistry
;
Cell Line
;
Chromatography, High Pressure Liquid
;
Culture Media, Conditioned
;
Dimerization
;
Docosahexaenoic Acids/*isolation & purification/*metabolism/pharmacology
;
Fatty Acids, Unsaturated/pharmacology
;
Histone Acetyltransferases
;
Humans
;
Ligands
;
Male
;
Mice
;
Nuclear Receptor Coactivator 1
;
Receptors, Retinoic Acid/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Retinoid X Receptors
;
Signal Transduction
;
Spectrometry, Mass, Electrospray Ionization
;
Transcription Factors/genetics/*metabolism
;
Transfection
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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