ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
Keywords
Publisher
Years
  • 1
    facet.materialart.
    Unknown
    Sustainability, Vol. 10, Pages 4005: Trust at a Distance—Trust in Online Communication in Environmental and Global Health Research Projects (2018)
    MDPI
    Details
    Publication Date: 2018
    Description: Online collaboration to deal with (global) environmental and public health problems continues to grow as the quality of technology for communication improves. In these collaborations, trust is seen as important for sustainable collaborations and organizations. However, face-to-face communication, which is often lacking in these contexts, is seen as a pre-requisite for trust development. Therefore, this paper aims to explore empirically which factors influence the emergence of trust in the early stages of online collaboration. Using the relevant literature, we conducted a series of interviews around projects in the field of public health and the environment on the interface between science and practice. The results show that trust does develop between participants. This trust is strongly influenced by perceived ability and integrity, fostered by reputation, third-party perceptions, and project structure. In these contexts, these types of trust facilitate collaboration but are also influenced by a wider set of aspects such as power, expectations, and uncertainty. However, from the results we also conclude that online collaboration does not create benevolence and a shared identity, thereby limiting further trust development and leading to less strong relations. Strong relations, however, are deemed important to reach creative and innovative solutions and long-term sustainable collaboration and organizations.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Antifreeze proteins control trehalose precipitates [Chemistry] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-06-15
    Description: The remarkable adaptive strategies of insects to extreme environments are linked to the biochemical compounds in their body fluids. Trehalose, a versatile sugar molecule, can accumulate to high levels in freeze-tolerant and freeze-avoiding insects, functioning as a cryoprotectant and a supercooling agent. Antifreeze proteins (AFPs), known to protect organisms from...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Pruning the regulatory tree (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-01-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Scott -- Ubel, Peter -- De Vries, Raymond -- England -- Nature. 2009 Jan 29;457(7229):534-5. doi: 10.1038/457534a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Michigan, 300 North Ingalls Street, Ann Arbor, MI 48109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19177111" target="_blank"〉PubMed〈/a〉
    Keywords: Clinical Trials as Topic/economics/ethics/*legislation & jurisprudence/standards ; Cost-Benefit Analysis ; Humans ; Informed Consent/ethics ; Patient Rights/*legislation & jurisprudence/*standards ; Risk Assessment ; United States
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Cancer regression in patients after transfer of genetically engineered lymphocytes (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-09-02
    Description: Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a retrovirus that encodes a T cell receptor. Adoptive transfer of these transduced cells in 15 patients resulted in durable engraftment at levels exceeding 10% of peripheral blood lymphocytes for at least 2 months after the infusion. We observed high sustained levels of circulating, engineered cells at 1 year after infusion in two patients who both demonstrated objective regression of metastatic melanoma lesions. This study suggests the therapeutic potential of genetically engineered cells for the biologic therapy of cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267026/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267026/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morgan, Richard A -- Dudley, Mark E -- Wunderlich, John R -- Hughes, Marybeth S -- Yang, James C -- Sherry, Richard M -- Royal, Richard E -- Topalian, Suzanne L -- Kammula, Udai S -- Restifo, Nicholas P -- Zheng, Zhili -- Nahvi, Azam -- de Vries, Christiaan R -- Rogers-Freezer, Linda J -- Mavroukakis, Sharon A -- Rosenberg, Steven A -- Z01 BC010763-01/Intramural NIH HHS/ -- Z01 SC003811-32/Intramural NIH HHS/ -- Z99 CA999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 6;314(5796):126-9. Epub 2006 Aug 31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16946036" target="_blank"〉PubMed〈/a〉
    Keywords: *Adoptive Transfer ; Adult ; Antigens, Neoplasm/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; Cancer Vaccines/therapeutic use ; Cells, Cultured ; Electroporation ; Female ; Genetic Engineering ; *Genetic Therapy ; HLA-A Antigens/immunology ; HLA-A2 Antigen ; Humans ; Interleukin-2/immunology/therapeutic use ; MART-1 Antigen ; Male ; Melanoma/immunology/secondary/*therapy ; Middle Aged ; Neoplasm Proteins/*immunology ; Receptors, Antigen, T-Cell, alpha-beta/*genetics/*immunology ; Transduction, Genetic ; Transgenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Enabling large-scale viscoelastic calculations via neural network acceleration (2017)
    Wiley
    Details
    Publication Date: 2017-03-04
    Description: One of the most significant challenges involved in efforts to understand the effects of repeated earthquake cycle activity are the computational costs of large-scale viscoelastic earthquake cycle models. Computationally intensive viscoelastic codes must be evaluated thousands of times and locations, and as a result, studies tend to adopt a few fixed rheological structures and model geometries, and examine the predicted time-dependent deformation over short (〈10 yr) time periods at a given depth after a large earthquake. Training a deep neural network to learn a computationally efficient representation of viscoelastic solutions, at any time, location, and for a large range of rheological structures, allows these calculations to be done quickly and reliably, with high spatial and temporal resolution. We demonstrate that this machine learning approach accelerates viscoelastic calculations by more than 50,000%. This magnitude of acceleration will enable the modeling of geometrically complex faults over thousands of earthquake cycles across wider ranges of model parameters and at larger spatial and temporal scales than have been previously possible.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    A Mycobacterium leprae-specific human T cell epitope cross-reactive with an HLA-DR2 peptide (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-10-14
    Description: Mycobacterium leprae induces T cell reactivity and protective immunity in the majority of exposed individuals, but the minority that develop leprosy exhibit various types of immunopathology. Thus, the definition of epitopes on M. leprae antigens that are recognized by T cells from different individuals might result in the development of an effective vaccine against leprosy. A sequence from the 65-kD protein of this organism was recognized by two HLA-DR2-restricted, M. leprae-specific helper T cell clones that were derived from a tuberculoid leprosy patient. Synthetic peptides were used to define this epitope as Leu-Gln-Ala-Ala-Pro-Ala-Leu-Asp-Lys-Leu. A similar peptide that was derived from the third hypervariable region of the HLA-DR2 chain, Glu-Gln-Ala-Arg-Ala-Ala-Val-Asp-Thr-Tyr, also activated the same clones. The unexpected cross-reactivity of this M. leprae-specific DR2-restricted T cell epitope with a DR2 peptide may have to be considered in the design of subunit vaccines against leprosy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, D C -- van Schooten, W C -- Barry, M E -- Janson, A A -- Buchanan, T M -- de Vries, R R -- AI-23982/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1988 Oct 14;242(4876):259-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Washington, Seattle 98195.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2459778" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Antibodies, Monoclonal ; Antigens, Bacterial/*immunology ; Epitopes/*immunology ; HLA-DR Antigens/*immunology ; HLA-DR2 Antigen ; Leprosy/immunology ; Molecular Sequence Data ; Mycobacterium leprae/*immunology ; Peptides/immunology ; T-Lymphocytes/*immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    What's better than Coulomb failure stress? A Ranking of Scalar Static Stress Triggering Mechanisms from 105 Mainshock-Aftershock Pairs (2017)
    Wiley
    Details
    Publication Date: 2017-11-17
    Description: Aftershocks may be triggered by the stresses generated by preceding mainshocks. The temporal frequency and maximum size of aftershocks are well described by the empirical Omori and Bath laws, but spatial patterns are more difficult to forecast. Coulomb failure stress is perhaps the most common criterion invoked to explain spatial distributions of aftershocks. Here we consider the spatial relationship between patterns of aftershocks and a comprehensive list of 38 static elastic scalar metrics of stress (including stress tensor invariants, maximum shear stress, and Coulomb failure stress) from 213 coseismic slip distributions worldwide. The rates of true-positive and false-positive classification of regions with and without aftershocks are assessed with receiver operating characteristic (ROC) analysis. We infer that the stress metrics that are most consistent with observed aftershock locations are maximum shear stress and the magnitude of the second and third invariants of the stress tensor. These metrics are significantly better than random assignment at a significance level of 0.005 in over 80% of the slip distributions. In contrast, the widely-used Coulomb failure stress criterion is distinguishable from random assignment in only 51-64% of the slip distributions. These results suggest that a number of alternative scalar metrics are better predictors of aftershock locations than classic Coulomb failure stress change.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    High-throughput identification of small molecules that affect human embryonic vascular development [Applied Biological Sciences] (2017)
    National Academy of Sciences
    Details
    Publication Date: 2017-04-12
    Description: Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based on prenatal animal testing; however, this approach yields low-throughput and...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Statistical tests of simple earthquake cycle models (2016)
    Wiley
    Details
    Publication Date: 2016-09-24
    Description: A central goal of observing and modeling the earthquake cycle is to forecast when a particular fault may generate an earthquake: a fault late in its earthquake cycle may be more likely to generate an earthquake than a fault early in its earthquake cycle. Models that can explain geodetic observations throughout the entire earthquake cycle may be required to gain a more complete understanding of relevant physics and phenomenology. Previous efforts to develop unified earthquake models for strike-slip faults have largely focused on explaining both pre- and post- seismic geodetic observations available across a few faults in California, Turkey, and Tibet. An alternative approach leverages the global distribution of geodetic and geologic slip rate estimates on strike-slip faults worldwide. Here, we use the Kolmogorov-Smirnov (KS) test for similarity of distributions to infer, in a statistically rigorous manner, viscoelastic earthquake cycle models that are inconsistent with 15 sets of observations across major strike-slip faults. We reject a large subset of two-layer models incorporating Burgers rheologies at a significance level of α = 0.05(those with long-term Maxwell viscosities η M  〈 ~ 4.0x10 19   Pa s and η M  〉 η M  〈 ~ 4.0x10 19 ~ 4.6x10 20 Pa∙s), but cannot reject models on the basis of transient Kelvin viscosity η K Finally, we examine the implications of these results for the predicted earthquake cycle timing of the 15 faults considered, and compare these predictions to the geologic and historical record.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    Electronic Resource
    Electronic Resource
    Low noise high-Tc superconducting bolometers on silicon nitride membranes for far-infrared detection (1997)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 4719-4726 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: High-Tc GdBa2Cu3O7−δ superconductor bolometers with operation temperatures near 89 K, large receiving areas of 0.95 mm2 and very high detectivity have been made. The bolometers are supported by 0.62 μm thick silicon nitride membranes. A specially developed silicon-on-nitride layer was used to enable the epitaxial growth of the high-Tc superconductor. Using a gold black absorption layer an absorption efficiency for wavelengths between 70 and 200 μm of about 83% has been established. The noise of the best devices is fully dominated by the intrinsic phonon noise of the thermal conductance G, and not by the 1/f noise of the superconducting film. The temperature dependence of the noise and the resulting optimum bias temperature have been investigated. In the analysis the often neglected effect of electrothermal feedback has been taken into account. The minimum electrical noise equivalent power (NEP) of a bolometer with a time constant τ of 95 ms is 2.9 pW/Hz1/2 which corresponds with an electrical detectivity D* of 3.4×1010 cm Hz1/2/W. Similar bolometers with τ=27 ms and NEP=3.8 pW/Hz1/2 were also made. No degradation of the bolometers could be observed after vibration tests, thermal cycling and half a year storage. Measurements of the noise of a Pr doped YBa2Cu3O7−δ film with Tc=40 K show that with such films the performance of air bridge type high-Tc bolometers could be improved. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.366327
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...