Publication Date:
1979-08-03
Description:
Heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on platelet aggregation. The PGI2-induced enhancement of platelet cyclic adenosine monophosphate levels is also inhibited. The mechanism appears to involve a direct interaction in which heparin neutralizes the inhibitory effects of PGI2 on platelet aggregation but, at the same time, does not lose its own anticoagulant activity. These findings may explain instances in which heparin infusions have been reported to produce hyperaggregation of platelets, thrombotic episodes, and thrombocytopenia in patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saba, H I -- Saba, S R -- Blackburn, C A -- Hartmann, R C -- Mason, R G -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):499-501.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/377493" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Diphosphate/pharmacology
;
Blood Coagulation/drug effects
;
Epoprostenol/*pharmacology
;
Heparin/*pharmacology
;
Humans
;
Kinetics
;
Platelet Aggregation/*drug effects
;
Prostaglandins/*pharmacology
;
Thrombin/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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