Publication Date:
1982-12-24
Description:
Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crews, S -- Barth, R -- Hood, L -- Prehn, J -- Calame, K -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1319-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146913" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Avian Myeloblastosis Virus/genetics
;
Chromosome Mapping
;
Chromosomes/*analysis
;
Mice
;
Nucleic Acid Hybridization
;
*Oncogenes
;
Plasmacytoma/*genetics
;
*Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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