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  • 1
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    Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-11-17
    Description: The circadian clock temporally coordinates metabolic homeostasis in mammals. Central to this is heme, an iron-containing porphyrin that serves as prosthetic group for enzymes involved in oxidative metabolism as well as transcription factors that regulate circadian rhythmicity. The circadian factor that integrates this dual function of heme is not known. We show that heme binds reversibly to the orphan nuclear receptor Rev-erbalpha, a critical negative component of the circadian core clock, and regulates its interaction with a nuclear receptor corepressor complex. Furthermore, heme suppresses hepatic gluconeogenic gene expression and glucose output through Rev-erbalpha-mediated gene repression. Thus, Rev-erbalpha serves as a heme sensor that coordinates the cellular clock, glucose homeostasis, and energy metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yin, Lei -- Wu, Nan -- Curtin, Joshua C -- Qatanani, Mohammed -- Szwergold, Nava R -- Reid, Robert A -- Waitt, Gregory M -- Parks, Derek J -- Pearce, Kenneth H -- Wisely, G Bruce -- Lazar, Mitchell A -- R01 DK45586/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Dec 14;318(5857):1786-9. Epub 2007 Nov 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18006707" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks ; Cell Line ; Cell Line, Tumor ; *Circadian Rhythm/genetics ; DNA-Binding Proteins/*metabolism ; Energy Metabolism ; *Gene Expression Regulation ; Gluconeogenesis/genetics ; Glucose/*metabolism ; Glucose-6-Phosphatase/genetics/metabolism ; Heme/*metabolism ; Hemin/pharmacology ; Histone Deacetylases/metabolism ; Homeostasis ; Humans ; Male ; *Metabolic Networks and Pathways ; Mice ; Nuclear Proteins/metabolism ; Nuclear Receptor Co-Repressor 1 ; Nuclear Receptor Subfamily 1, Group D, Member 1 ; Receptors, Cytoplasmic and Nuclear/*metabolism ; Repressor Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis of Adenosine Triphosphate by a Protonmotive Force in Rat Liver Mitochondria (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 257-258 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ACCORDING to the chemiosmotic hypothesis of oxidative and photosynthetic phosphorylation1, the "oligomycin sensitive" ATPase of mitochondria2 and the " 'Dio-9' sensitive" ATPase of chloroplasts3 reversibly couple the translocation of hydrogen ions across the cristae or lamellae membrane to the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/212257a0
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  • 3
    Electronic Resource
    Electronic Resource
    Culture of Strain L Cells in Suspension: Replacement of Polymer by Traces of Trypsin in A Defined Medium (1963)
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 982-984 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] METHODS for the culture of tissue cells en masse have been studied in a number of laboratories1-5 with the view of opening up to the student of tissue cells the valuable cytostat and washed suspension techniques familiar to the microbiologist. All the methods described so far, however, fall short ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/197982a0
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  • 4
    Electronic Resource
    Electronic Resource
    Selfish DNA in ‘Petite’ mutants (1980)
    [s.l.] : Nature Publishing Group
    Nature 285 (1980), S. 620-620 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DIRECT experimental evidence of DNA arising in eukaryotes by non-phenotypic selection is furnished by 'petite' mutations of the mitochondrial DNA of Sac-charomyces cerevisiae. These mutants are promising systems for investigating the questions raised by Orgel and Crickl on the molecular mechanisms ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/285620b0
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  • 5
    Electronic Resource
    Electronic Resource
    The rate of acidification of aquatic ecosystems in Ontario, Canada (1987)
    [s.l.] : Nature Publishing Group
    Nature 329 (1987), S. 45-48 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Alkalinity distribution of lakes in central Ontario. A total of 1,787 lakes were surveyed in the years 1981-85. All lakes were in the SO4-deposition zone defined as having SO2," deposition of 〉60mequiv m~2 yr"1. Upper limit of alkalinity interval (pequiv. I"1) We have studied two ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/329045a0
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  • 6
    Electronic Resource
    Electronic Resource
    Changes in the chemistry of lakes near Subury, Ontario following reductions of SO2 emissions (1986)
    Springer
    Water, air & soil pollution 31 (1986), S. 59-65 
    Details
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Emissions of SO2 in the Sudbury area declined from an estimated average of 1.41 × 106 tonne yr−1 in 1973–78 to 0.68 × 106 tonne yr−1 in 1979–85. As a result, SO4 concentrations of lakes in the area have decreased, and the pH of each of the acidic lakes that was studied has increased. Aluminum, Cu, Ni and Zn concentrations have also decreased; however, the latter three metals have probably declined because of reductions in emissions of metals from the smelters rather than because of the pH changes in the lakes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630819
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  • 7
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    A method for estimating the height of a mesospheric density level using meteor radar (2015)
    Wiley
    Details
    Publication Date: 2015-07-08
    Description: A new technique for determining the height of a constant density surface at altitudes of 78–85 km is presented. The first results are derived from a decade of observations by a meteor radar located at Davis Station in Antarctica and are compared with observations from the Microwave Limb Sounder instrument aboard the Aura satellite. The density of the neutral atmosphere in the mesosphere/lower thermosphere region around 70–110 km is an essential parameter for interpreting airglow derived atmospheric temperatures, planning atmospheric entry maneuvers of returning spacecraft, and understanding the response of climate to different stimuli. This region is not well characterized however, due to inaccessibility combined with a lack of consistent strong atmospheric radar scattering mechanisms. Recent advances in the analysis of detection records from high performance meteor radars provide new opportunities to obtain atmospheric density estimates at high time resolutions in the MLT region using the durations and heights of faint radar echoes from meteor trails. Previous studies have indicated that the expected increase in underdense meteor radar echo decay times with decreasing altitude is reversed in the lower part of the meteor ablation region due to the neutralization of meteor plasma. The height at which the gradient of meteor echo decay times reverses is found to occur at a fixed atmospheric density. Thus, the gradient reversal height of meteor radar diffusion coefficient profiles can be used to infer the height of a constant density level, enabling the observation of mesospheric density variations using meteor radar.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 8
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    Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉The instructive capabilities of extracellular matrix–inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment. We previously demonstrated that nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffolds efficiently induced osteoprogenitor differentiation and bone healing. In this work, we combined adenovirus-mediated delivery of osteoprotegerin (AdOPG), an endogenous anti-osteoclastogenic decoy receptor, in primary human mesenchymal stem cells (hMSCs) with MC-GAG to understand the role of osteoclast inactivation in augmentation of bone regeneration. Simultaneous differentiation of osteoprogenitors on MC-GAG and osteoclast progenitors resulted in bidirectional positive regulation. AdOPG expression did not affect osteogenic differentiation alone. In the presence of both cell types, AdOPG-transduced hMSCs on MC-GAG diminished osteoclast-mediated resorption in direct contact; however, osteoclast-mediated augmentation of osteogenic differentiation was unaffected. Thus, the combination of OPG with MC-GAG may represent a method for uncoupling osteogenic and osteoclastogenic differentiation to augment bone regeneration.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Growth of non-polar (11-20) InGaN quantum dots by metal organic vapour phase epitaxy using a two temperature method (2014)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2014-12-13
    Description: Non-polar (11-20) InGaN quantum dots (QDs) were grown by metal organic vapour phase epitaxy. An InGaN epilayer was grown and subjected to a temperature ramp in a nitrogen and ammonia environment before the growth of the GaN capping layer. Uncapped structures with and without the temperature ramp were grown for reference and imaged by atomic force microscopy. Micro-photoluminescence studies reveal the presence of resolution limited peaks with a linewidth of less than ∼500 μ eV at 4.2 K. This linewidth is significantly narrower than that of non-polar InGaN quantum dots grown by alternate methods and may be indicative of reduced spectral diffusion. Time resolved photoluminescence studies reveal a mono-exponential exciton decay with a lifetime of 533 ps at 2.70 eV. The excitonic lifetime is more than an order of magnitude shorter than that for previously studied polar quantum dots and suggests the suppression of the internal electric field. Cathodoluminescence studies show the spatial distribution of the quantum dots and resolution limited spectral peaks at 18 K.
    Electronic ISSN: 2166-532X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by American Institute of Physics (AIP)
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  • 10
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    The effects of de-ionization processes on meteor radar diffusion coefficients below 90 km (2014)
    Wiley
    Details
    Publication Date: 2014-08-12
    Description: The decay times of VHF radar echoes from underdense meteor trails are reduced in the lower portions of the meteor region. This is a result of plasma neutralization initiated by the attachment of positive trail ions to neutral atmospheric molecules. Decreased echo decay times cause meteor radars to produce erroneously high estimates of the ambipolar diffusion coefficient at heights below 90 km, which affects temperature estimation techniques. Comparisons between co-located radars and satellite observations show that meteor radar estimates of diffusion coefficients are not consistent with estimates from the Aura MLS satellite instrument and that co-located radars operating at different frequencies estimate different values of the ambipolar diffusion coefficient for simultaneous detections of the same meteors. Loss of free electrons from meteor trails due to attachment to aerosols and chemical processes were numerically simulated and compared with observations to determine the specific mechanism responsible for low altitude meteor trail plasma neutralization. It is shown that three-body attachment of positive metal ions significantly reduces meteor radar echo decay times at low altitudes compared to the case of diffusion only, that atmospheric ozone plays little part in the evolution of low-altitude underdense meteor trails, and that the effect of three-body attachment begins to exceed diffusion in echo decay times at a constant density surface.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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