Publication Date:
2010-09-11
Description:
Repeated study improves memory, but the underlying neural mechanisms of this improvement are not well understood. Using functional magnetic resonance imaging and representational similarity analysis of brain activity, we found that, compared with forgotten items, subsequently remembered faces and words showed greater similarity in neural activation across multiple study in many brain regions, including (but not limited to) the regions whose mean activities were correlated with subsequent memory. This result addresses a longstanding debate in the study of memory by showing that successful episodic memory encoding occurs when the same neural representations are more precisely reactivated across study episodes, rather than when patterns of activation are more variable across time.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952039/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952039/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xue, Gui -- Dong, Qi -- Chen, Chuansheng -- Lu, Zhonglin -- Mumford, Jeanette A -- Poldrack, Russell A -- HD057884-01A2/HD/NICHD NIH HHS/ -- R01 HD057884/HD/NICHD NIH HHS/ -- R01 HD057884-01A2/HD/NICHD NIH HHS/ -- R01 HD057884-02/HD/NICHD NIH HHS/ -- R01 HD057884-03/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2010 Oct 1;330(6000):97-101. doi: 10.1126/science.1193125. Epub 2010 Sep 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20829453" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
Adult
;
Brain/*physiology
;
Brain Mapping
;
Face
;
Female
;
Frontal Lobe/physiology
;
Humans
;
Learning/physiology
;
Magnetic Resonance Imaging
;
Male
;
Memory/*physiology
;
Mental Recall/*physiology
;
Parietal Lobe/physiology
;
Recognition (Psychology)
;
Temporal Lobe/physiology
;
Visual Cortex/physiology
;
Young Adult
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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