ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    A high speed compact microwave interferometer for density fluctuation measurements in Sino-UNIted Spherical Tokamak (2016)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2016-08-04
    Description: A single-channel 3 mm interferometer has been developed for plasma density diagnostics in the Sino-UNIted Spherical Tokamak (SUNIST). The extremely compact microwave interferometer utilizes one corrugated feed horn antenna for both emitting and receiving the microwave. The beam path lies on the equatorial plane so the system would not suffer from beam path deflection problems due to the symmetry of the cross section. A focusing lens group and an oblique vacuum window are carefully designed to boost the signal to noise ratio, which allows this system to show good performance even with the small-diameter central column itself as a reflector, without a concave mirror. The whole system discards the reference leg for maximum compactness, which is particularly suitable for the small-sized tokamak. An auto-correcting algorithm is developed to calculate the phase evolution, and the result displays good phase stability of the whole system. The intermediate frequency is adjustable and can reach its full potential of 2 MHz for best temporal resolution. Multiple measurements during ohmic discharges proved the interferometer’s capability to track typical density fluctuations in SUNIST, which enables this system to be utilized in the study of MHD activities.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Published by American Institute of Physics (AIP)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    A new cluster-type statistical model for the prediction of deformation textures (2015)
    Institute of Physics (IOP)
    Details
    Publication Date: 2015-04-26
    Description: An attempt was done to improve the quality of deformation texture predictions by statistical models through the introduction of "clusters" of N grains thus defining a third, intermediate length scale. The interaction between each cluster and the macroscopic length scale is of the Taylor type, whereas inside each cluster a VPSC scheme is used. Predictions of cold rolling deformation textures were quantitatively compared with experimental results for a steel alloy. The results are encouraging.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Identification of drug-target interaction from interactome network with 'guilt-by-association principle and topology features (2016)
    Oxford University Press
    Details
    Publication Date: 2016-03-26
    Description: Motivation: Identifying drug–target protein interaction is a crucial step in the process of drug research and development. Wet-lab experiment are laborious, time-consuming and expensive. Hence, there is a strong demand for the development of a novel theoretical method to identify potential interaction between drug and target protein. Results: We use all known proteins and drugs to construct a nodes- and edges-weighted biological relevant interactome network. On the basis of the ‘guilt-by-association’ principle, novel network topology features are proposed to characterize interaction pairs and random forest algorithm is employed to identify potential drug–protein interaction. Accuracy of 92.53% derived from the 10-fold cross-validation is about 10% higher than that of the existing method. We identify 2272 potential drug–target interactions, some of which are associated with diseases, such as Torg-Winchester syndrome and rhabdomyosarcoma. The proposed method can not only accurately predict the interaction between drug molecule and target protein, but also help disease treatment and drug discovery. Contacts: zhanchao8052@gmail.com or ceszxy@mail.sysu.edu.cn Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua (2018)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2018
    Description: 〈p〉〈i〉Artemisia annua〈/i〉 produces the valuable medicinal component, artemisinin, which is a sesquiterpene lactone widely used in malaria treatment. AaORA, a homolog of CrORCA3, which is involved in activating terpenoid indole alkaloid biosynthesis in 〈i〉Catharanthus roseus〈/i〉, is a jasmonate (JA)–responsive and trichome-specific APETALA2/ETHYLENE-RESPONSE FACTOR that plays a pivotal role in artemisinin biosynthesis. However, the JA signaling mechanism underlying AaORA-mediated artemisinin biosynthesis remains enigmatic. Here, we report that AaORA forms a transcriptional activator complex with AaTCP14 (TEOSINTE BRANCHED 1/CYCLOIDEA/PROLIFERATING CELL FACTOR 14), which is also predominantly expressed in trichomes. AaORA and AaTCP14 synergistically bind to and activate the promoters of two genes, 〈i〉double bond reductase 2〈/i〉 (〈i〉DBR2〈/i〉) and 〈i〉aldehyde dehydrogenase 1〈/i〉 (〈i〉ALDH1〈/i〉), both of which encode enzymes vital for artemisinin biosynthesis. AaJAZ8, a repressor of the JA signaling pathway, interacts with both AaTCP14 and AaORA and represses the ability of the AaTCP14-AaORA complex to activate the 〈i〉DBR2〈/i〉 promoter. JA treatment induces AaJAZ8 degradation, allowing the AaTCP14-AaORA complex to subsequently activate the expression of 〈i〉DBR2〈/i〉, which is essential for artemisinin biosynthesis. These data suggest that JA activation of the AaTCP14-AaORA complex regulates artemisinin biosynthesis. Together, our findings reveal a novel artemisinin biosynthetic pathway regulatory network and provide new insight into how specialized metabolism is modulated by the JA signaling pathway in plants.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    AMPK pathway and IGF1 secretion [Medical Sciences] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-06-30
    Description: Tre-2/USP6, BUB2, cdc16 domain family member 1 (the TBC domain is the GTPase activating protein domain) (TBC1D1) is a Rab GTPase activating protein that is phosphorylated on Ser231 by the AMP-activated protein kinase (AMPK) in response to intracellular energy stress. However, the in vivo role and importance of this phosphorylation...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Reciprocal inhibition between miR-26a and NF-{kappa}B regulates obesity-related chronic inflammation in chondrocytes (2015)
    Portland Press
    Details
    Publication Date: 2015-04-26
    Description: Obesity is causally linked to osteoarthritis, with the mechanism being not fully elucidated. MicroRNAs are pivotal regulators of various diseases in multiple tissues, including inflammation in the chondrocytes. Here we for the first time identified the expression of miR-26a in mouse chondrocytes. Decreased level of miR-26a was correlated to increased chronic inflammation in the chondrocytes and circulation in obese mouse model. Mechanistically, we demonstrated that miR-26a attenuated saturated free fatty acid-induced activation of NF-κB (p65) and production of proinflammatory cytokines in chondrocytes. Meanwhile, NF-κB (p65) also suppressed miR-26a production by directly binding to a predicted NF-κB binding element in the promoter region of miR-26a. Finally, we observed a negative correlation between NF-κB and miR-26a in human patients with osteoarthritis. Thus, we identified a reciprocal inhibition between miR-26a and NF-κB downstream of free fatty acid signaling in obesity-related chondrocytes. Our findings provide a potential mechanism linking obesity to cartilage inflammation.
    Print ISSN: 0144-8463
    Electronic ISSN: 1573-4935
    Topics: Biology , Chemistry and Pharmacology
    Published by Portland Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Nano suboxide layer generated in Ta2O5 by Ar+ ion irradiation (2015)
    American Institute of Physics (AIP)
    Details
    Publication Date: 2015-01-22
    Description: Ta 2 O 5 /TaO x heterostructure has become a leading oxide layer in memory cells and/or a bidirectional selector for resistive random access memory (RRAM). Although atomic layer deposition (ALD) was found to be uniquely suitable for depositing uniform and conformal films on complex topographies, it is hard to use ALD to grow suboxide TaO x layer. In this study, tantalum oxide films with a composition of Ta 2 O 5 were grown by ALD. Using Ar + ion irradiation, the suboxide was formed in the top layer of Ta 2 O 5 films by observing the Ta core level shift toward lower binding energy with angle-resolved X-ray photoelectron spectroscopy. By controlling the energy and irradiation time of an Ar + ion beam, Ta 2 O 5 /TaO x heterostructure can be reliably produced on ALD films, which provides a way to fabricate the critical switching layers of RRAM.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
    Published by American Institute of Physics (AIP)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Effect of the grain shape on the q-value evolution of steel sheets (2015)
    Institute of Physics (IOP)
    Details
    Publication Date: 2015-04-26
    Description: Two polycrystalline plasticity models, namely the ALAMEL model and the viscoplastic self-consistent (VPSC) model were used to study the effect of the grain shape on the evolution of plastic anisotropy. The latter was characterized by the q-value in this paper. The two models both predict the evolution of grain shape and texture and then can predict the effect of the initial grain shape on the texture. The final anisotropy of the materials was also assessed with the help of these models. Data of tensile tests in three directions for three low carbon steel sheets with either equiaxed or a pancake grain shape were used to evaluate the model predictions. Both models give the same trend of the grain shape effect on the evolution of the q-values. Results demonstrate that the effect of the grain shape can be clearly reflected in the x-value distribution as defined and discussed in this paper. But it is not so obvious in the predicted textures for the investigated three materials accordi...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats (2013)
    Springer Nature
    Details
    Publication Date: 2013-02-22
    Description: Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats Cell Death and Disease 4, e501 (February 2013). doi:10.1038/cddis.2013.35 Authors: K Sun, X-l Guo, Q-d Zhao, Y-y jing, X-r Kou, X-q Xie, Y Zhou, N Cai, L Gao, X Zhao, S-s Zhang, J-r Song, D Li, W-j Deng, R Li, M-c Wu & L-x Wei
    Keywords: autophagyhepatocarcinoma developmentdifferent stagesparadoxical roleROS
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation (2016)
    Oxford University Press
    Details
    Publication Date: 2016-02-24
    Description: Atrial septal defects (ASDs) are a common human congenital heart disease (CHD) that can be induced by genetic abnormalities. Our previous studies have demonstrated a genetic interaction between Tbx5 and Osr1 in the second heart field (SHF) for atrial septation. We hypothesized that Osr1 and Tbx5 share a common signaling networking and downstream targets for atrial septation. To identify this molecular networks, we acquired the RNA-Seq transcriptome data from the posterior SHF of wild-type , Tbx5 +/ – , Osr1 +/– , Osr1 –/– and Tbx5 +/– /Osr1 +/– mutant embryos. Gene set analysis was used to identify the Kyoto Encyclopedia of Genes and Genomes pathways that were affected by the doses of Tbx5 and Osr1 . A gene network module involving Tbx5 and Osr1 was identified using a non-parametric distance metric, distance correlation. A subset of 10 core genes and gene–gene interactions in the network module were validated by gene expression alterations in posterior second heart field (pSHF) of Tbx5 and Osr1 transgenic mouse embryos, a time-course gene expression change during P19CL6 cell differentiation. Pcsk6 was one of the network module genes that were linked to Tbx5. We validated the direct regulation of Tbx5 on Pcsk6 using immunohistochemical staining of pSHF, ChIP-quantitative polymerase chain reaction and luciferase reporter assay. Importantly, we identified Pcsk6 as a novel gene associated with ASD via a human genotyping study of an ASD family. In summary, our study implicated a gene network involving Tbx5 , Osr1 and Pcsk6 interaction in SHF for atrial septation, providing a molecular framework for understanding the role of Tbx5 in CHD ontogeny.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
    Published by Oxford University Press
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...