ISSN:
1420-9071
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In the absence of divalent cations, ionophore A23187 supports low rates of monovalent cations loss (Na+〉K+) from unilamellar liposomes containing the sulfate salts. Monovalent cation efflux is optimal when a pH gradient (interior alkaline) is applied. The maximum observed rate of 0.56 ngion K+·min−1·nmole−1 A23187 is insufficient to account for the rates of K+ efflux induced by the ionophore in mitochondria (150 ngion K+·min−1·nmole−1 A23187). These studies therefore support the concept that A23187 induces loss of K+ from mitochondria by removal of regulating divalent cations from an endogenous K+/H+ exchanger.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01959740
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