ISSN:
1573-904X
Keywords:
4(3H)-quinazolinones
;
synthesis
;
guanidino moiety
;
antihypertensive
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Two 2-substituted 4(3H)-quinazolinones were synthesized through an easy one-step synthetic procedure. One of them (1), which was synthesized by the reaction of l-(2-hydroxyphenyl)-2-thiourea and isatoic anhydride, contained a guanidino moiety and showed antihypertensive activity following cumulative intravenous administration to anesthetized spontaneously hypertensive rats. The other compound (2) does not contain the guanidino group and did not exhibit antihypertensive activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015949931218
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