ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Antibodies to the erythrocyte Ag-C antigens were raised by immunizing New Zealand white rabbits with rat red cells. Evidence that Ag-C antigens are not on lymphocytes includes: (1) Ag-C could not be detected on rat peripheral, splenic or thymic lymphocytes by lymphocytotoxicity using anti-Ag-C antisera, (2) xeno-antisera prepared against rat lymphocytes from which Ag-B antibodies were absorbed did not agglutinate rat red cells, and (3) absorption of reagent Ag-C antisera with lymphocytes did not remove the anti-Ag-C activity. Platelets also failed to absorb Ag-C antibodies from reagent anti-Ag-C antisera. The mixed lymphocyte reaction between strains within the same major histocompatibility (Ag-B) group but differing in Ag-C type showed no stimulation. This finding corroborates the studies which failed to demonstrate Ag-C on lymphocytes. Isoagglutinins for red cells were not detected in any of the strains of rats tested, but rabbit xenoagglutinins to rat and sheep red cells were found. Reagent Ag-C antisera were used to type some previously unreported strains of inbred rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1975.tb00521.x
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