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  • 1
    Electronic Resource
    Electronic Resource
    Preheating study by reflectivity measurements in laser-driven shocks (1998)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 5 (1998), S. 2410-2420 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A study on preheating effects in laser-driven shock waves is presented. Two different diagnostics were used: the color temperature measurement deduced by recording the target rear side emissivity in two spectral bands, and the rear surface reflectivity measurement by using a probe beam. In order to test the response of the two diagnostics to the preheating, three types of targets characterized by different radiative properties were used. The greater sensitivity of the second diagnostic compared with the first was demonstrated. A model which calculates the reflectivity using a one-dimensional hydrodynamic code data was developed. In this model, the wave propagation equations in the expanding plasma using an appropriate model for the electron–ion collision frequency applicable to the cold solid-hot plasma transition were solved. The comparison between the calculated and measured reflectivities allows us to estimate the preheating process. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.872917
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid quantitation of N-dipripylacetamide in human plasma by gas-liquid chromatography
    Amsterdam : Elsevier
    Journal of Chromatography A 174 (1979), S. 231-233 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)87059-4
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  • 3
    Electronic Resource
    Electronic Resource
    Coherent backscattering of electromagnetic waves in a magnetised plasma (1996)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 18 (1996), S. 823-838 
    Details
    ISSN: 0392-6737
    Keywords: Plasma interactions ; Radio-frequency and microwave measurements ; Diffraction and scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary A microwave coherent backscattering experiment has been carried out on Mirabelle, a weakly ionised plasma device, with the objective of measuring the electron density fluctuation level. The experiment is a preliminary step in order to prepare the detection system for a microwave stimulated backscattering experiment. The incident electromagnetic wave is focused in front of a plane grid which excites ion acoustic or electron Bernstein waves inducing fluctuations in the plasma. The backscattering signal is collected by the launching circuit and detected by homodyne mixing. The typical ratio of the scattered power to the incident power is about 10−12 and the relative density fluctuations are of the order of δn e/n e=10−3 against a background electron density ofn e=1–5·109 cm−3. The backscattering measurement is compared with Langmuir probe measurements. The spectral width of the backscattered signal has also been studied, by taking into account effects due to the incident wave focusing and plasma wave damping.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02457315
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  • 4
    Electronic Resource
    Electronic Resource
    Single-dose kinetics of primidone in acute viral hepatitis (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 465-469 
    Details
    ISSN: 1432-1041
    Keywords: primidone ; viral hepatitis ; single-dose kinetics ; primidone metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of primidone (PRM) after oral administration of a single 500 mg dose was studied in 7 patients with acute viral hepatitis and 7 healthy control subjects. The elimination half-life and the apparent clearance of unchanged PRM in the patients were 18.0±3.1 h and 42±14 ml·h−1·kg−1, respectively (mean ± SD) and did not differ significantly from the values in the controls (half-life 17.0±2.4 h; clearance 35±8 ml·h−1·kg−1). The metabolite phenylethylmalonamide (PEMA) was detected in the serum of all normal subjects within 2–24 h. By contrast, serum levels of this metabolite were undetectable (〈2 umol/l) in all but one of the patients. Serum levels of phenobarbital (PB) remained below the limit of detection (〈2 µmol/l) in all subjects. The findings indicate that accumulation of PRM with its attendant toxicity is unlikely to occur in epileptic patients who develop acute viral hepatitis, despite evidence that the metabolism of the drug is affected by this condition. The possibility of impaired conversion to PB and its implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00549596
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 289-291 
    Details
    ISSN: 1432-1041
    Keywords: valnoctamide ; valpromide ; valproic acid ; pharmacokinetics ; healthy subjects ; tranquiliser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a single 400 mg oral dose of valnoctamide (VCD) has been investigated in seven healthy, adult, male volunteers. VCD was not biotransformed rapidly to its corresponding acid valnoctic acid (VCA), unlike its isomer valpromide (VPD). It had a mean residence time of 13.2 h and a terminal half-life of 9.3 h. Throughout the study, only low plasma levels of VCA could be detected. Thus, unlike VPD, which is a prodrug of the corresponding acid, (valproic acid, VPA). VCD appears to act as a drug in its own right, and it does not undergo similar hydrolysis. The pharmacokinetic difference may account for the different pharmacological activities of the two isomers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315032
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  • 6
    Electronic Resource
    Electronic Resource
    Domain organization and biochemical features of Sulfolobus solfataricus DNA polymerase (1998)
    Springer
    Extremophiles 2 (1998), S. 171-177 
    Details
    ISSN: 1433-4909
    Keywords: Key wordsSulfolobus solfataricus ; DNA replication ; DNA polymerase ; 3′-5′ Exonuclease ; Modular organization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract DNA polymerase from Sulfolobus solfataricus, strain MT4 (Sso DNA pol), was one of the first archaeal DNA polymerases to be isolated and characterized. Its encoding gene was cloned and sequenced, indicating that Sso DNA pol belongs to family B of DNA polymerases. By limited proteolysis experiments carried out on the recombinant homogeneous protein, we were able to demonstrate that the enzyme has a modular organization of its associated catalytic functions (DNA polymerase and 3′-5′ exonuclease). Indeed, the synthetic function was ascribed to the enzyme C-terminal portion, whereas the N-terminal half was found to be responsible for the exonucleolytic activity. In addition, partial proteolysis studies were utilized to map conformational changes on DNA binding by comparing the cleavage map in the absence or presence of nucleic acid ligands. This analysis allowed us to identify two segments of the Sso DNA pol amino acid chain affected by structural modifications following nucleic acid binding: region 1 and region 2, in the middle and at the C-terminal end of the protein chain, respectively. Site-directed mutagenesis studies will be performed to better investigate the role of these two protein segments in DNA substrate interaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007920050057
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  • 7
    Electronic Resource
    Electronic Resource
    Molecular biology of extremophiles (1995)
    Springer
    World journal of microbiology and biotechnology 11 (1995), S. 71-84 
    Details
    ISSN: 1573-0972
    Keywords: Archaea ; gene expression ; genetics ; replication ; thermophile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The molecular biology of extremophiles has recently attracted much interest, both in terms of cell adaptation to extreme environmental conditions and the development of manipulative genetic techniques. Although molecular genetic techniques have been successfully applied to halophiles and methanogens, their use with hyperthermophiles is limited by the extreme growth conditions that these organisms require. Much information on the thermophilic Archaea, has been obtained by studying the key enzymes involved in fundamental cell processes, such as transcription and replication, and by the cloning, sequence comparison and heterologous expression of structural genes. The development of viral vectors and systems for transformation, mutant production and screening will permit increased genetic manipulation of these organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339137
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  • 8
    Electronic Resource
    Electronic Resource
    Zur Analyse der Meteoriten (1869)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 8 (1869), S. 508-508 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01462470
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  • 9
    Electronic Resource
    Electronic Resource
    Entdeckung der Zirconerde neben Titansäure (1865)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 4 (1865), S. 416-417 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01347440
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  • 10
    Electronic Resource
    Electronic Resource
    Maassanalytische Bestimmung des Molybdäns (1865)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 4 (1865), S. 420-421 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01347443
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