Publikationsdatum:
2005-11-16
Beschreibung:
Glucocorticoids (GC) are keystone drugs in the treatment of childhood ALL and therefore it is important to get more insight in signal transduction pathways involved in GC induced apoptosis. Affymetrix U133A GeneChips were used to identify genes that are transcriptionally regulated upon 3 and 8 hours of prednisolone exposure in leukemic cells of 13 children newly diagnosed with ALL. After 3 hours of exposure no changes in gene expression could yet be found. After 8 hours exposure, 57 probesets (51 unique genes) were differentially expressed (p
Print ISSN:
0006-4971
Digitale ISSN:
1528-0020
Thema:
Biologie
,
Medizin
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