ISSN:
1432-1041
Keywords:
verapamil
;
bendrofluazide
;
hypertension
;
adverse effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effects of verapamil and bendrofluazide used singly and in combination were examined in patients with primary hypertension in a patient blind, partly observer blind placebo controlled study of parallel group design; there were ten subjects in each arm of the trial. Verapamil 160 mg twice daily caused supine mean arterial pressure to fall by 21 mm Hg; this reduction was significantly greater (p〈0.05) than that induced by bendrofluazide 5 mg daily which caused a fall of only 10 mm Hg. The addition of verapamil 160 mg twice daily to bendrofluazide 5 mg daily caused a further fall in pressure of 18 mm Hg (p〈0.005), but the reduction in pressure when bendrofluazide was added to verapamil was only 1 mm Hg and not significant. Bendrofluazide therapy caused a fall in plasma potassium concentration and an increase in plasma urate concentration; urinary calcium excretion was reduced. Verapamil caused no detectable biochemical alterations in plasma or urine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00540951
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