Publication Date:
1997-05-30
Description:
STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine. STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation. Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfeffer, L M -- Mullersman, J E -- Pfeffer, S R -- Murti, A -- Shi, W -- Yang, C H -- New York, N.Y. -- Science. 1997 May 30;276(5317):1418-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9162009" target="_blank"〉PubMed〈/a〉
Keywords:
Acute-Phase Proteins/*genetics
;
Amino Acid Sequence
;
Androstadienes/pharmacology
;
Animals
;
Binding Sites
;
COS Cells
;
Cell Line
;
Cloning, Molecular
;
Conserved Sequence
;
DNA-Binding Proteins/genetics/*metabolism
;
Enzyme Inhibitors/pharmacology
;
Membrane Proteins
;
Molecular Sequence Data
;
Phosphatidylinositol 3-Kinases
;
Phosphorylation
;
Phosphotransferases (Alcohol Group Acceptor)/antagonists &
;
inhibitors/genetics/*metabolism
;
Point Mutation
;
Protein Binding
;
Receptor, Interferon alpha-beta
;
Receptors, Interferon/*metabolism
;
Recombinant Fusion Proteins/genetics/metabolism
;
STAT3 Transcription Factor
;
Signal Transduction
;
Trans-Activators/genetics/*metabolism
;
Tyrosine/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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