Publication Date:
2014-01-01
Description:
Objective. The aim of this study was to investigate the association of functionalMMP-1-1607 1G/2G andMMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these polymorphisms to different clinical features of women with SPTB.Methods and Patients. A case-control study was conducted in 113 women with SPTB and 119 women with term delivery (control group). Genotyping ofMMP-1-1607 1G/2G andMMP-9-1562 C/T gene polymorphisms was performed using the combination of polymerase chain reaction and restriction fragment length polymorphism methods.Results. There were no statistically significant differences in the distribution of neither individual nor combinations of genotype and allele frequencies ofMMP-1-1607 1G/2G andMMP-9-1562 C/T polymorphisms between women with SPTB and control women. Additionally, these polymorphisms do not contribute to any of the clinical characteristics of women with SPTB, including positive and negative family history of SPTB, gestational age at delivery, and maternal age at delivery, nor fetal birth weight.Conclusion. We did not find the evidence to support the association ofMMP-1-1607 1G/2G andMMP-9-1562 C/T gene polymorphisms with SPTB in European Caucasian women.
Print ISSN:
0278-0240
Electronic ISSN:
1875-8630
Topics:
Biology
,
Chemistry and Pharmacology
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