ISSN:
0170-2041
Keywords:
Pyrazino[2,3-c]-1,2,6-thiadiazine
;
Folic acid analogues
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3-c]-1,2,6-thiadiazine 2,2-dioxide system incorporating the glutamic acid side chain at the 7-position is described. No significant DHFR inhibition of cytotoxic activity has been found with these compounds.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199119910152
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