ISSN:
1573-4838
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
,
Technik allgemein
Notizen:
Abstract Natural coral skeleton (NCS) has recently been proposed as a bone graft substitute that enhances bone formation. The present paper describes the effects of implanting NCS in bone cavities prepared in the mandibles of miniature pig, and compares these with the effects of two alloplastic materials; a tricalcium phosphate (TCP) and a porous hydroxyapatite (PHA). On 11 pigs, 5 × 5 mm windows were created through alveolar bone of the four mandibular incisors. Three cavities were filled with the various materials and the fourth was left unfilled. The animals were slaughtered at 0, 1, 2, 4, 12, 26 and 52 weeks post-operatively and the tissues were examined histologically. Healing completed at 26 weeks for NCS and TCP, and at 52 weeks for PHA. NCS granules provided surface for cell attachment and deposition of a distinguishable organic matrix two weeks post-operatively. This matrix developed to bone after four weeks. The granules gradually resorbed and were replaced by bone at 52 weeks. The excellent properties of NCS, biocompatibility, porosity and osteogenic effect make us suggest that it might be a suitable replacement for bone grafting.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00713454
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