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  • 1
    Electronic Resource
    Electronic Resource
    Histidine-Rich Glycoprotein and Platelet Factor 4 Mask Heparan Sulfate Proteoglycans Recognized by Acidic and Basic Fibroblast Growth Factor (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 13918-13927 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00250a047
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-HIV-1 Activity of Chemically Modified Heparins: Correlation between Binding to the V3 Loop of gp120 and Inhibition of Cellular HIV-1 Infection in vitro (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 6974-6980 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00188a029
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of Passive Allergic Encephalomyelitis by Sulfated Polysaccharides (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb27166.x
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  • 4
    Electronic Resource
    Electronic Resource
    Ability of different chemically modified heparins to potentiate the biological activity of heparin-binding growth factor 1. Lack of correlation with growth factor binding (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 6498-6503 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00143a020
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of antigens recognized by xenogeneic and allogeneic anti-Ia antibodies: Evidence for two classes of Ia antigens (1978)
    Springer
    Immunogenetics 6 (1978), S. 343-354 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Previously published data suggest that both xenogeneic and allogeneic anti-Ia sera can recognize carbohydrate-defined antigenic determinants on the surface of lymphocytes. There is also evidence, based on studies with allogeneic anti-Ia sera, that protein-defined Ia antigens exist. In this paper the relationship between these two types of Ia antigen was examined. It was found that in capping studies, the allogeneic anti-Ia serum could cap off the antigens recognized by the xenogeneic antiserum, whereas the xenogeneic antibodies could, at least partially, clear the surface of lymphocytes of Ia antigens detected by the allogeneic antibodies. On the other hand, when immunoprecipitates of radioiodinated cell-surface antigens were examined by SDS-polyacrylamide-gel electrophoresis, it was found that the xenogeneic anti-Ia serum did not immunoprecipitate any labeled material. In contrast, the allogeneic antiserum immunoprecipitated a labeled molecule which corresponded to the protein-defined Ia antigen described by others. Finally, it was shown that serum Ia antigens could be bound by either mouse or rabbit anti-Ia antibody, and this binding blocked any further reactivity with either serum. These results were interpreted as suggesting that two separate classes of Ia antigen molecule appear on the lymphocyte surface-one class has carbohydrate-defined antigenic specificities and the other has protein-defined determinants. Allogeneic anti-Ia sera contain antibodies against both these antigenic systems, whereas xenogeneic sera recognize only the carbohydratedefined series. The genetic implications of this interpretation are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01563926
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  • 6
    Electronic Resource
    Electronic Resource
    Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis (1999)
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 803-809 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA sequence of the human platelet enzyme, which encodes a unique protein of 543 amino acids, and the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/10525
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  • 7
    Electronic Resource
    Electronic Resource
    The human Ia system: Definition and characterization by xenogeneic antisera (1979)
    Springer
    Immunogenetics 8 (1979), S. 185-200 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The production of xenogeneic anti-Ia serum against Ia antigens in serum has been previously described in the mouse and we now describe the production of xenogeneic anti-human Ia antisera using similar methods. With an indirect resetting technique, Ia-like antibodies were shown to react with the majority of B cells (95%), a subpopulation of T cells, with carbonyl iron adherent cells, and with some E−Ig− null cells, but there was no reaction with red cells and platelets. These reactions were the same as those obtained with DRW antisera using cytotoxicity testing. In addition, antigens detected with xenogeneic antisera were also found in serum, where they were found to exist in a low molecular weight, dialyzable form. By the selective removal of different cell surface markers by cocapping, no association could be found with the specifities detected with the xenogeneic anti-Ia antisera and with surface Ig,β 2-microglobulin, or HLA-A and B specificities. Alloantibodies to DRW specificities (but not HLA-A, B specificities) were able to specifically block the binding of the rabbit anti-Ia antibodies to B cells, and reciprocal blocking of rabbit antisera by DRW antibodies was also observed. Several xenogenic antisera were produced by immunizing rabbits with the serum of different individuals. Each antiserum was shown to contain a number of different specificities, as they gave different reaction patterns with different individuals when testing was done both directly and by absorption. These xenogeneic anti-la sera also segregated in a family with HLA-A and B specificities. The detection of a polymorphic antigenic system segregating with the HLA complex, distinct from HLA-A and B specificities, and whose antigens occur predominantly on B cells is therefore described. Because of the similarity of the reactions of the xenogeneic antisera in man to those found in the mouse, and because of the close relationship to the DRW specificities, the system has been provisionally called the ‘H.Ia’ system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561429
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  • 8
    Electronic Resource
    Electronic Resource
    A detailed serological analysis of a xenogeneic anti-Ia serum (1978)
    Springer
    Immunogenetics 6 (1978), S. 183-196 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Rabbit anti-mouse-Ia serum was raised against Ia specificities present in CBAJH (H-2 k) serum. This xenogeneic antiserum was considered to react with similar specificities to those detected by mouse anti-Iak alloantisera and more evidence is now presented for this contention. By absorption, the xenogeneic antiserum was found to react with spleen, lymph node, bone marrow, and thymus, reactions similar to that found with the allogeneic anti-Iak antiserum. Furthermore, red cells, platelets, brain, kidney, and liver could not absorb the activity from the xenogeneic antiserum, demonstrating the selective tissue distribution of the antigens reactive with this serum. This reactive population was previously shown to consist of B cells and a subpopulation of T cells. In a backcross study of (C57BL/6 × A)F1 × C57BL/6, the rabbit anti-Ia and mouse anti-Ia reactions were found to segregate together, and some evidence for the genetic regulation of the expression of Ia specificities was also found. By direct testing, and by absorption testing using a number of strains, the xenogeneic antiserum was shown to contain high titers of antibody to Ia.1′, 3′, 7′, 15′, and 17′; lower titers to Ia.19′, and 22′; little antibody to Ia.18′, and no reaction for the private specificity Ia. 2, although the multiple absorptions required to define these specificities may have observed some reactions. The data indicate that the xenogeneic and allogeneic anti-Iak antisera recognize similar Ia determinants, which map to theLA, IE andIC subregions of theH-2 complex. These have been given the same specificity designation as the allogeneic specificities, but they are separately identified by a prime (').
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01563908
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  • 9
    Electronic Resource
    Electronic Resource
    Low molecular weight Ia antigens in normal mouse serum (1976)
    Springer
    Immunogenetics 3 (1976), S. 129-137 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Substantial quantities of low molecular weight Ia antigens can be detected in normal mouse serum. In contrast, it was found that athymicnu/nu and ATxBM mice, both of which are deprived of T lymphocytes, had little or no Ia in their serum. Furthermore, antilymphocyte serum (ALS) treatment, which is believed to deplete the pool of long-lived recirculating T cells, eliminated Ia antigens from serum, whereas adult thymectomy (ATx), which depletes short-lived T cells, had no effect on the Ia levels. This data strongly suggests that Ia antigens are secreted by long-lived recirculating T cells. The T-cell origin of the serum Ia antigens was confirmed in vitro, where it was found that a population of nonadherent Thy-1+, Ig− spleen cells rapidly secreted Ia. The ability of spleen cells from ALS-treated and ATx mice to secrete Ia antigen in vitro also corresponded to the levels of Ia in the sera of these mice. Furthermore, procedures which resulted in activation of T cells —such as multiple injections of antigen, graft-versus-host reactions, and injections of mitogens—produced large increases (from 10- to 50-fold) in both the Ia concentrations in serum and the rates of Ia secretion in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576945
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  • 10
    Electronic Resource
    Electronic Resource
    Low molecular weight Ia antigens in normal mouse serum (1976)
    Springer
    Immunogenetics 3 (1976), S. 113-128 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The observation that mouse serum can specifically inhibit cytotoxic Ia antisera indicates that substantial quantities of Ia antigen are present in normal mouse serum. The inhibitory substance in serum is dialyzable and is therefore probably of low molecular weight; it presumably represents a degraded form of cell-bound Ia antigen. A rabbit antiserum specific for murine Ia antigens was obtained by immunizing rabbits with mouse serum and then absorbing the resultant antiserum with dialyzed mouse serum. The binding of this antiserum to mouse leucocytes was detected by an indirect rosetting technique. The specificity of this antiserum was established as follows: (a) serum from mouse strains which possessed the corresponding Ia specificities absorbed out the antileucocyte antibodies; (b) binding of the rabbit antibody to leucocytes was inhibited by mouse anti-Ia sera but not by mouse antibodies against other regions of theH-2 complex; (c) conversely, binding of mouse cytotoxic Ia antibodies to leucocytes was specifically blocked by the rabbit antiserum; (d) antisera produced in rabbits against serum from recombinant mouse strains showed the correct Ia specificities. The rabbit anti-Ia serum was used to demonstrate that 90% of splenic B cells and 40 to 50% of splenic T cells are Ia+. in order of content of Ia+ cells, the different lymphoid populations were ranked spleen 〉 thymus 〉 bone marrow 〉 peripheral blood 〉 lymph node.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01576944
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