ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
L-Phenylalanine has been treated with chlorosulfonic acid and the product was either hydrolyzed, ammonolyzed or reduced. The resulting sulfonic-acid and aminosulfonyl derivatives have been employed for peptide synthesis with Boc-protection of the Nα-position only. The reduction product L-(4′-SH)Phe has been protected by formation of asymmetric disulfides or with various thiol protecting groups (benzyl-, methyl- and acetamidomethyl groups, the latter being the most suitable for peptide synthesis).With these protected amino acids several analogues of angiotensin II have been synthesized by the solid-phase method. These analogues have been used for structure-activity relationship studies on three different bioassays.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19830660504
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