ISSN:
1573-8221
Keywords:
visual perception
;
evoked potentials
;
fluacizine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Electrophysiological manifestations of disturbed visual perception were studied in 18 healthy volunteers following blockade of M-cholinergic brain structures with the tricyclic antidepressant fluacizine given orally in a single dose of 1 mg/kg. The synchronization of spontaneous electroencephalographic activity observed 2 h after dosing indicated that the cholinergic structures were stably blocked. Evoked potentials were recorded in response to presented images having identical physical parameters but differing in information content (a checkerboard, slanting bands, or circles). When the amplitudetime characteristics of components of visual evoked potential were analyzed, the brain's electrical response to presented stimuli was found to be altered as compared to the initial (predosing) state: perception of physical parameters of the stimuli was distorted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445820
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