Publication Date:
1982-01-15
Description:
Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M C -- Picciano, P T -- Douglas, W J -- Yoshida, T -- Kreutzer, D L -- Cohen, S -- AI-12477/AI/NIAID NIH HHS/ -- HL-25015/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797069" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Line
;
Cell Migration Inhibition
;
Cell Movement/drug effects
;
Endothelium/cytology/*drug effects
;
Humans
;
Leukocyte Migration-Inhibitory Factors/pharmacology
;
Lymphokines/*pharmacology
;
Macrophages/drug effects
;
Mast-Cell Sarcoma/physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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