Publication Date:
2012-03-03
Description:
A major challenge in biology is to understand how buds comprising a few cells can give rise to complex plant and animal appendages like leaves or limbs. We address this problem through a combination of time-lapse imaging, clonal analysis, and computational modeling. We arrive at a model that shows how leaf shape can arise through feedback between early patterns of oriented growth and tissue deformation. Experimental tests through partial leaf ablation support this model and allow reevaluation of previous experimental studies. Our model allows a range of observed leaf shapes to be generated and predicts observed clone patterns in different species. Thus, our experimentally validated model may underlie the development and evolution of diverse organ shapes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuchen, Erika E -- Fox, Samantha -- de Reuille, Pierre Barbier -- Kennaway, Richard -- Bensmihen, Sandra -- Avondo, Jerome -- Calder, Grant M -- Southam, Paul -- Robinson, Sarah -- Bangham, Andrew -- Coen, Enrico -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Mar 2;335(6072):1092-6. doi: 10.1126/science.1214678.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉John Innes Centre, Norwich Research Park, Norwich, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22383846" target="_blank"〉PubMed〈/a〉
Keywords:
Antirrhinum/anatomy & histology/genetics/growth & development
;
Arabidopsis/anatomy & histology/genetics/growth & development
;
Arabidopsis Proteins/genetics/metabolism
;
Cell Polarity
;
Computer Simulation
;
Genes, Plant
;
*Models, Biological
;
*Morphogenesis
;
Plant Leaves/*anatomy & histology/cytology/*growth & development
;
Time-Lapse Imaging
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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