Publication Date:
2009-01-24
Description:
Regeneration of injured neurons can restore function, but most neurons regenerate poorly or not at all. The failure to regenerate in some cases is due to a lack of activation of cell-intrinsic regeneration pathways. These pathways might be targeted for the development of therapies that can restore neuron function after injury or disease. Here, we show that the DLK-1 mitogen-activated protein (MAP) kinase pathway is essential for regeneration in Caenorhabditis elegans motor neurons. Loss of this pathway eliminates regeneration, whereas activating it improves regeneration. Further, these proteins also regulate the later step of growth cone migration. We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729122/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729122/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hammarlund, Marc -- Nix, Paola -- Hauth, Linda -- Jorgensen, Erik M -- Bastiani, Michael -- 1R21NS060275/NS/NINDS NIH HHS/ -- NS034307/NS/NINDS NIH HHS/ -- R21 NS060275-02/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2009 Feb 6;323(5915):802-6. doi: 10.1126/science.1165527. Epub 2009 Jan 22.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112-0840, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19164707" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Axons/*physiology/ultrastructure
;
Axotomy
;
Caenorhabditis elegans/genetics/*physiology
;
Caenorhabditis elegans Proteins/genetics/*metabolism
;
Growth Cones/physiology
;
MAP Kinase Kinase 4/genetics/metabolism
;
MAP Kinase Kinase Kinases/genetics/*metabolism
;
*MAP Kinase Signaling System
;
Mitogen-Activated Protein Kinases/genetics/metabolism
;
Models, Biological
;
Motor Neurons/*physiology
;
Mutation
;
Nerve Regeneration/physiology
;
RNA Interference
;
gamma-Aminobutyric Acid/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink