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  • 1
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    Leveraging bias to your advantage (2020)
    Springer Nature
    Details
    Publication Date: 2020
    Print ISSN: 1552-4450
    Electronic ISSN: 1552-4469
    Topics: Biology , Chemistry and Pharmacology
    Published by Springer Nature
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  • 2
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    Crustal structures, geophysical models, and contemporary tectonism of the Colorado plateau (1979)
    In:  Tectonophys., New York, Allerton Press, vol. 61, no. 29, pp. 131-147, pp. 2152, (ISSN: 1340-4202)
    Details
    Publication Date: 1979
    Keywords: Velocity depth profile ; Modelling ; Tectonics ; USA
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    BIBLIOGRAPHY SEISMOLOGY
  • 3
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    The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity (2015)
    Wiley
    Details
    Publication Date: 2015-08-12
    Description: Direct application of histone-deacetylase-inhibitors (HDACis) to dental pulp cells (DPCs) induces chromatin changes, promoting gene expression and cellular-reparative events. We have previously demonstrated that HDACis (Valproic acid, Trichostatin A) increase mineralization in dental papillae-derived cell-lines and primary DPCs by stimulation of dentinogenic gene expression. Here, we investigated novel genes regulated by the HDACi, suberoylanilide hydroxamic acid (SAHA), to identify new pathways contributing to DPC differentiation. SAHA significantly compromised DPC viability only at relatively high concentrations (5 μM); while low concentrations (1 μM) SAHA did not increase apoptosis. HDACi-exposure for 24 h induced mineralization-per-cell dose-dependently after 2 weeks; however, constant 14d SAHA-exposure inhibited mineralization. Microarray analysis (24 h and 14d) of SAHA exposed cultures highlighted that 764 transcripts showed a significant 〉2.0-fold change at 24 h, which reduced to 36 genes at 14d. 59% of genes were down-regulated at 24 h and 36% at 14d, respectively. Pathway analysis indicated SAHA increased expression of members of the matrix metalloproteinase (MMP) family. Furthermore, SAHA-supplementation increased MMP-13 protein expression (7d, 14 d) and enzyme activity (48 h, 14d). Selective MMP-13-inhibition (MMP-13i) dose-dependently accelerated mineralization in both SAHA-treated and non-treated cultures. MMP-13i-supplementation promoted expression of several mineralization-associated markers, however, HDACi-induced cell migration and wound healing were impaired. Data demonstrate that short-term low-dose SAHA-exposure promotes mineralization in DPCs by modulating gene pathways and tissue proteases. MMP-13i further increased mineralization-associated events, but decreased HDACi cell migration indicating a specific role for MMP-13 in pulpal repair processes. Pharmacological inhibition of HDAC and MMP may provide novel insights into pulpal repair processes with significant translational benefit. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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  • 4
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    Setting spatial conservation priorities despite incomplete data for characterizing metapopulations (2016)
    Wiley
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    Publication Date: 2016-08-05
    Description: Management of spatially structured species poses unique challenges. Despite a strong theoretical foundation, practitioners rarely have sufficient empirical data to evaluate how populations interact. Rather, assumptions about connectivity and source-sink dynamics are often based on incomplete, extrapolated or modeled data, if such interactions are even considered at all. Therefore, it has been difficult to evaluate whether spatially structured species are meeting conservation goals. We evaluated how estimated metapopulation structure responded to estimates of population sizes and dispersal probabilities, and to the set of populations included. We then compared outcomes of alternative management strategies that target conservation of metapopulation processes. We illustrated these concepts for Chinook salmon ( Oncorhynchus tshawytscha ) in the Snake River, USA. Our description of spatial structure for this metapopulation was consistent with previous characterizations. We found substantial differences in estimated metapopulation structure when we had incomplete information about all populations and when we used different sources of data (3 empirical, 2 modeled) to estimate dispersal, whereas responses to population size estimates were more consistent. Together, these findings suggest that monitoring efforts should target all populations occasionally and populations that play key roles frequently, and that multiple types of data should be collected when feasible. When empirical data are incomplete or of uneven quality, analyses using estimates produced from an ensemble of available datasets can help conservation planners and managers weigh near-term options. Doing so, we found tradeoffs in connectivity and source dominance in metapopulation-level responses to alternative management strategies that suggest which types of approaches may be inherently less risky. This article is protected by copyright. All rights reserved.
    Print ISSN: 1051-0761
    Electronic ISSN: 1939-5582
    Topics: Biology
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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  • 5
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    Evidence of central Alpine glacier advances during the Younger Dryas–early Holocene transition period (2016)
    Wiley
    In: Boreas
    Details
    Publication Date: 2016-02-24
    Description: The transition phase from Lateglacial to Holocene climate conditions was accompanied by a pronounced reorganization of climate patterns in the Northern Hemisphere. Evidence of Alpine palaeoglaciers provides a basis for understanding climate downturns during a time of generally warming conditions. In this context a series of well-preserved and previously undated moraines were investigated in the small Falgin cirque located in the central Alpine Langtaufers Valley (South Tyrol, Italy) and in the neighbouring Hinteres Bergle cirque of the Radurschl Valley (North Tyrol, Austria). Both localities are situated in the driest area of the eastern Alps. They lie well above prominent moraines associated with the Younger Dryas (YD) cold phase and represent the first moraines below Little Ice Age (LIA) positions. The corresponding equilibrium line altitude of the palaeoglaciers in both cirques was 100–120 m lower than during the LIA. Surface exposure dating ( 10 Be) of the inner Falgin moraines shows a mean stabilization age of 11.2±0.9 ka, which is similar to the deglaciation age of 10.9±0.8 ka for the Hinteres Bergle cirque. The ages indicate glacier activity most likely during the earliest Holocene or the YD/Holocene transition. These findings point to a climate with mean summer temperatures about 1.5 °C lower than during the 20th century in the Alps.
    Print ISSN: 0300-9483
    Electronic ISSN: 1502-3885
    Topics: Geography , Geosciences
    Published by Wiley
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  • 6
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    Liquid crystal self-assembly of random-sequence DNA oligomers [Applied Physical Sciences] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-01-25
    Description: In biological systems and nanoscale assemblies, the self-association of DNA is typically studied and applied in the context of the evolved or directed design of base sequences that give complementary pairing, duplex formation, and specific structural motifs. Here we consider the collective behavior of DNA solutions in the distinctly different regime where DNA base sequences are chosen at random or with varying degrees of randomness. We show that in solutions of completely random sequences, corresponding to a remarkably large number of different molecules, e.g., approximately 1012 for random 20-mers, complementary still emerges and, for a narrow range of oligomer lengths, produces a subtle hierarchical sequence of structured self-assembly and organization into liquid crystal (LC) phases. This ordering follows from the kinetic arrest of oligomer association into long-lived partially paired double helices, followed by reversible association of these pairs into linear aggregates that in turn condense into LC domains.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160 (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-01-24
    Description: Simian immunodeficiency virus (SIV) is a primate lentivirus related to human immunodeficiency viruses and is an etiologic agent for acquired immunodeficiency syndrome (AIDS)-like diseases in macaques. To date, only inactivated whole virus vaccines have been shown to protect macaques against SIV infection. Protective immunity was elicited by recombinant subunit vaccines. Four Macaca fascicularis were immunized with recombinant vaccinia virus expressing SIVmne gp160 and were boosted with gp160 produced in baculovirus-infected cells. All four animals were protected against an intravenous challenge of the homologous virus at one to nine animal-infectious doses. These results indicate that immunization with viral envelope antigens alone is sufficient to elicit protective immunity against a primate immunodeficiency virus. The combination immunization regimen, similar to one now being evaluated in humans as candidate human immunodeficiency virus (HIV)-1 vaccines, appears to be an effective way to elicit such immune responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hu, S L -- Abrams, K -- Barber, G N -- Moran, P -- Zarling, J M -- Langlois, A J -- Kuller, L -- Morton, W R -- Benveniste, R E -- AI26503/AI/NIAID NIH HHS/ -- R01 AI28065/AI/NIAID NIH HHS/ -- RR00166/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1992 Jan 24;255(5043):456-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1531159" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; DNA, Viral/genetics ; Gene Products, env ; Genetic Vectors ; Lymphocyte Activation ; Macaca fascicularis ; Molecular Sequence Data ; Neutralization Tests ; Oligonucleotides/chemistry ; Polymerase Chain Reaction ; Simian Acquired Immunodeficiency Syndrome/immunology/*prevention & control ; Simian Immunodeficiency Virus/*immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Time Factors ; Vaccination ; Vaccines, Synthetic/*immunology ; Viral Vaccines/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition [Microbiology] (2017)
    National Academy of Sciences
    Details
    Publication Date: 2017-06-14
    Description: The Target of Rapamycin (TOR) pathway regulates morphogenesis and responses to host cells in the fungal pathogen Candida albicans. Eukaryotic Target of Rapamycin complex 1 (TORC1) induces growth and proliferation in response to nitrogen and carbon source availability. Our unbiased genetic approach seeking unknown components of TORC1 signaling in C....
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Third-person self-talk facilitates emotion regulation without engaging cognitive control: Converging evidence from ERP and fMRI (2017)
    Springer Nature
    Details
    Publication Date: 2017-07-04
    Description: Third-person self-talk facilitates emotion regulation without engaging cognitive control: Converging evidence from ERP and fMRI Scientific Reports, Published online: 3 July 2017; doi:10.1038/s41598-017-04047-3
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 10
    Electronic Resource
    Electronic Resource
    Alignment system for crossed parabolic x-ray mirrors (2000)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 2292-2295 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe the implementation of a crossed graded parabolic x-ray mirror system that is suitable for incorporation into both conventional and high resolution x-ray diffraction systems. A novel optical alignment system has been devised that permits independent adjustment of the positions and the angular settings of the mirrors. This alignment system is simple and inexpensive to construct, yet is mechanically stable and easy to use. The crossed mirror system has been successfully introduced into both protein crystallography and high resolution x-ray diffraction systems. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1150444
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    Paper (German National Licenses)
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