Publication Date:
1992-11-27
Description:
Synaptic events at the neuromuscular junction are integer multiples of a quantum, the postsynaptic response to transmitter released from one presynaptic vesicle. At central synapses where quanta are small, it has been suggested they are invariant due to occupation of all postsynaptic receptors, a concept neglecting inherent fluctuations in channel behavior. If this did occur, the quantal release model would not apply there and could not be used to localize sites of synaptic modification. Monte Carlo simulations of quanta include transmitter diffusion and interactions with postsynaptic receptors that are treated probabilistically. These models suggest that when there are few postsynaptic channels available at a synapse, their stochastic behavior produces significant intrinsic variance in response amplitude and kinetics, and saturation does not occur. These results were confirmed by analysis of inhibitory quanta in embryonic and adult Mauthner cells involving a small and large number of channels, respectively. The findings apply to excitatory synapses as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faber, D S -- Young, W S -- Legendre, P -- Korn, H -- NS21848/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1992 Nov 27;258(5087):1494-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurobiology Laboratory, State University of New York, Buffalo 14214.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1279813" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Diffusion
;
Goldfish
;
Ion Channels/physiology
;
*Models, Neurological
;
Models, Statistical
;
Monte Carlo Method
;
Neurotransmitter Agents/*metabolism
;
Receptors, Neurotransmitter/*physiology
;
Stochastic Processes
;
Synapses/*physiology
;
Synaptic Transmission/*physiology
;
Zebrafish
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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