Publication Date:
1996-01-12
Description:
The rostral hypothalamus and adjacent basal forebrain participate in the generation of sleep, but the neuronal circuitry involved in this process remains poorly characterized. Immunocytochemistry was used to identify the FOS protein, an immediate-early gene product, in a group of ventrolateral preoptic neurons that is specifically activated during sleep. The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral preoptic neurons innervate the tuberomammillary nucleus, a posterior hypothalamic cell group thought to participate in the modulation of arousal. This monosynaptic pathway in the hypothalamus may play a key role in determining sleep-wake states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sherin, J E -- Shiromani, P J -- McCarley, R W -- Saper, C B -- MH10709/MH/NIMH NIH HHS/ -- NS22835/NS/NINDS NIH HHS/ -- NS30140/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1996 Jan 12;271(5246):216-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8539624" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain Chemistry
;
Cholera Toxin
;
Circadian Rhythm
;
Immunohistochemistry
;
Mammillary Bodies/*physiology
;
Neural Pathways
;
Neurons/chemistry/*physiology
;
Preoptic Area/cytology/*physiology
;
Proto-Oncogene Proteins c-fos/analysis
;
Rats
;
Sleep/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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