Publikationsdatum:
1992-04-17
Beschreibung:
Max is a basic-helix-loop-helix-leucine zipper protein capable of forming sequence-specific DNA binding complexes with Myc proteins. An alternatively spliced messenger RNA has been identified that encodes a form of Max truncated at the COOH-terminus. This delta Max protein retained the ability to bind to the CACGTG motif in a complex with c-Myc but lacks the nuclear localization signal and the putative regulatory domain of Max. When tested in a myc-ras cotransformation assay in rat embryo fibroblasts, Max suppressed, whereas delta Max enhanced, transformation. Thus, the max gene may encode both a negative and a positive regulator of c-Myc function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makela, T P -- Koskinen, P J -- Vastrik, I -- Alitalo, K -- New York, N.Y. -- Science. 1992 Apr 17;256(5055):373-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Virology, University of Helsinki, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1566084" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amino Acid Sequence
;
Animals
;
Base Sequence
;
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
;
Basic-Leucine Zipper Transcription Factors
;
Binding Sites
;
Cell Nucleus/metabolism
;
Cell Transformation, Neoplastic/*drug effects/genetics
;
DNA/chemistry/metabolism
;
DNA-Binding Proteins/genetics/metabolism/*pharmacology
;
Fibroblasts
;
*Genes, myc
;
*Genes, ras
;
Humans
;
Immunosorbent Techniques
;
Molecular Sequence Data
;
Polymerase Chain Reaction
;
Proto-Oncogene Proteins c-myc/genetics/metabolism
;
RNA Splicing
;
RNA, Messenger/genetics
;
Rats
;
Structure-Activity Relationship
;
*Transcription Factors
;
Transfection
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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