Publication Date:
1983-01-28
Description:
Transplants of embryonic substantia nigra reinnervated the striatum and were able to sustain intracranial self-stimulation in rats with brain lesions induced by 6-hydroxydopamine. Dopaminergic drugs and alterations in current intensity produced typical changes in response rates. Animals with electrodes implanted into cortical grafts or into the denervated striatum failed to exhibit self-stimulation. These findings suggest that transplanted dopamine neurons convey specific, temporally organized information axonally to the striatum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fray, P J -- Dunnett, S B -- Iversen, S D -- Bjorklund, A -- Stenevi, U -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):416-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849143" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Caudate Nucleus/cytology
;
Corpus Striatum/*cytology
;
Dextroamphetamine/pharmacology
;
Dopamine/*physiology
;
Female
;
Flupenthixol/pharmacology
;
Putamen/cytology
;
Rats
;
Self Stimulation/*physiology
;
Substantia Nigra/*transplantation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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