Publication Date:
1980-04-11
Description:
A series of cyanine dyes used in photography, with reduction potentials from -1.35 to -0.20 volts, were tested for their ability to inhibit mitosis and cell growth in fertilized sea urchin eggs. Low concentrations of dyes with reduction potentials more negative than -1.0 volt generally inhibited mitosis and growth, whereas those with more positive reduction potentials did not. The active dyes penetrated the cell, entered all subcellular compartments, were bound to numerous macromolecules, and inhibited synthesis of macromolecules. Thus mitosis and growth may be retarded with substances that can alter electrochemical activity in cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zigman, S -- Gilman, P Jr -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):188-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361115" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carbocyanines/pharmacology
;
Cell Division/*drug effects
;
Coloring Agents/*pharmacology
;
Female
;
Growth/drug effects
;
Mitosis/*drug effects
;
Ovum/drug effects
;
Oxidation-Reduction
;
Sea Urchins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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