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  • 1
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    RIOK2: straddling the kinase/ATPase line (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1474-1776
    Electronic ISSN: 1474-1784
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer Nature
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  • 2
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    Granular segregation in a thin drum rotating with periodic modulation (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-11-25
    Description: Author(s): Richard D. P. East, Philippa McGuinness, Finn Box, Tom Mullin, and Iker Zuriguel We present the results of an experimental investigation into the effects of a sinusoidal modulation of the rotation rate on the segregation patterns formed in thin drum of granular material. The modulation transforms the base pattern formed under steady conditions by splitting or merging the initial... [Phys. Rev. E 90, 052205] Published Mon Nov 24, 2014
    Keywords: Granular Materials
    Print ISSN: 1539-3755
    Electronic ISSN: 1550-2376
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-07-26
    Description: Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion. A second set of eco1-1 suppressors inactivate the budding yeast ortholog of the cohesin destabilizer Wapl. Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rolef Ben-Shahar, Tom -- Heeger, Sebastian -- Lehane, Chris -- East, Philip -- Flynn, Helen -- Skehel, Mark -- Uhlmann, Frank -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):563-6. doi: 10.1126/science.1157774.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln'sInn Fields, London WC2A 3PX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653893" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Acetyltransferases/chemistry/genetics/*metabolism ; Alleles ; Cell Cycle Proteins/chemistry/genetics/*metabolism ; Chondroitin Sulfate Proteoglycans/chemistry/genetics/*metabolism ; Chromatids/*physiology ; Chromosomal Proteins, Non-Histone/chemistry/genetics/*metabolism ; Chromosomes, Fungal/*physiology ; DNA Repair ; DNA Replication ; DNA, Fungal/metabolism ; Mutation ; Nuclear Proteins/chemistry/genetics/*metabolism ; Protein Subunits/chemistry/genetics/metabolism ; S Phase ; Saccharomyces cerevisiae/genetics/growth & development/*physiology ; Saccharomyces cerevisiae Proteins/chemistry/genetics/*metabolism ; Suppression, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-03-27
    Description: Alternative messenger RNA splicing is the main reason that vast mammalian proteomic complexity can be achieved with a limited number of genes. Splicing is physically and functionally coupled to transcription, and is greatly affected by the rate of transcript elongation. As the nascent pre-mRNA emerges from transcribing RNA polymerase II (RNAPII), it is assembled into a messenger ribonucleoprotein (mRNP) particle; this is the functional form of the nascent pre-mRNA and determines the fate of the mature transcript. However, factors that connect the transcribing polymerase with the mRNP particle and help to integrate transcript elongation with mRNA splicing remain unclear. Here we characterize the human interactome of chromatin-associated mRNP particles. This led us to identify deleted in breast cancer 1 (DBC1) and ZNF326 (which we call ZNF-protein interacting with nuclear mRNPs and DBC1 (ZIRD)) as subunits of a novel protein complex--named DBIRD--that binds directly to RNAPII. DBIRD regulates alternative splicing of a large set of exons embedded in (A + T)-rich DNA, and is present at the affected exons. RNA-interference-mediated DBIRD depletion results in region-specific decreases in transcript elongation, particularly across areas encompassing affected exons. Together, these data indicate that the DBIRD complex acts at the interface between mRNP particles and RNAPII, integrating transcript elongation with the regulation of alternative splicing.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378035/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378035/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Close, Pierre -- East, Philip -- Dirac-Svejstrup, A Barbara -- Hartmann, Holger -- Heron, Mark -- Maslen, Sarah -- Chariot, Alain -- Soding, Johannes -- Skehel, Mark -- Svejstrup, Jesper Q -- A3560/Cancer Research UK/United Kingdom -- Cancer Research UK/United Kingdom -- England -- Nature. 2012 Mar 25;484(7394):386-9. doi: 10.1038/nature10925.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Mechanisms of Transcription Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms EN6 3LD, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22446626" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Proteins, Signal Transducing/genetics/metabolism ; *Alternative Splicing ; Animals ; Carrier Proteins/genetics/metabolism ; Chromatin/genetics/metabolism ; Exons/genetics ; HEK293 Cells ; Heterogeneous-Nuclear Ribonucleoproteins/deficiency/metabolism ; Humans ; Mice ; Multiprotein Complexes/*chemistry/genetics/*metabolism ; RNA Interference ; RNA Polymerase II/*metabolism ; RNA, Messenger/*biosynthesis/*genetics/metabolism ; Ribonucleoproteins/chemistry/genetics/metabolism ; *Transcription, Genetic
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    HMGA2 functions as a competing endogenous RNA to promote lung cancer progression (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-12-07
    Description: Non-small-cell lung cancer (NSCLC) is the most prevalent histological cancer subtype worldwide. As the majority of patients present with invasive, metastatic disease, it is vital to understand the basis for lung cancer progression. Hmga2 is highly expressed in metastatic lung adenocarcinoma, in which it contributes to cancer progression and metastasis. Here we show that Hmga2 promotes lung cancer progression in mouse and human cells by operating as a competing endogenous RNA (ceRNA) for the let-7 microRNA (miRNA) family. Hmga2 can promote the transformation of lung cancer cells independent of protein-coding function but dependent upon the presence of let-7 sites; this occurs without changes in the levels of let-7 isoforms, suggesting that Hmga2 affects let-7 activity by altering miRNA targeting. These effects are also observed in vivo, where Hmga2 ceRNA activity drives lung cancer growth, invasion and dissemination. Integrated analysis of miRNA target prediction algorithms and metastatic lung cancer gene expression data reveals the TGF-beta co-receptor Tgfbr3 (ref. 12) as a putative target of Hmga2 ceRNA function. Tgfbr3 expression is regulated by the Hmga2 ceRNA through differential recruitment to Argonaute 2 (Ago2), and TGF-beta signalling driven by Tgfbr3 is important for Hmga2 to promote lung cancer progression. Finally, analysis of NSCLC-patient gene-expression data reveals that HMGA2 and TGFBR3 are coordinately regulated in NSCLC-patient material, a vital corollary to ceRNA function. Taken together, these results suggest that Hmga2 promotes lung carcinogenesis both as a protein-coding gene and as a non-coding RNA; such dual-function regulation of gene-expression networks reflects a novel means by which oncogenes promote disease progression.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886898/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886898/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kumar, Madhu S -- Armenteros-Monterroso, Elena -- East, Philip -- Chakravorty, Probir -- Matthews, Nik -- Winslow, Monte M -- Downward, Julian -- 13-0142/Worldwide Cancer Research/United Kingdom -- 323145/European Research Council/International -- A3570/Cancer Research UK/United Kingdom -- A7419/Cancer Research UK/United Kingdom -- Cancer Research UK/United Kingdom -- England -- Nature. 2014 Jan 9;505(7482):212-7. doi: 10.1038/nature12785. Epub 2013 Dec 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Bioinformatics and Biostatistics Group, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Advanced Sequencing Facility, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Department of Genetics, Department of Pathology, the Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA. ; 1] Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK [2] Lung Cancer Group, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24305048" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Argonaute Proteins/metabolism ; Binding, Competitive/genetics ; Carcinoma, Non-Small-Cell Lung/genetics/pathology ; Cell Line, Tumor ; Cell Proliferation ; Disease Models, Animal ; *Disease Progression ; Gene Expression Regulation, Neoplastic/genetics ; HMGA2 Protein/*genetics ; Humans ; Lung Neoplasms/*genetics/*pathology ; Mice ; MicroRNAs/genetics/metabolism ; Neoplasm Invasiveness/genetics ; Neoplasm Metastasis/genetics ; Proteoglycans/biosynthesis/deficiency/genetics ; RNA Isoforms/genetics/metabolism ; Receptors, Transforming Growth Factor beta/biosynthesis/deficiency/genetics ; Transcription, Genetic/genetics ; Transforming Growth Factor beta/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Measuring Kinase Activity – A Global Challenge (2017)
    Wiley
    Details
    Publication Date: 2017-05-03
    Description: The kinase enzymes within a cell, known collectively as the kinome, play crucial roles in many signaling pathways, including survival, motility, differentiation, stress response, and many more. Aberrant signaling through kinase pathways is often linked to cancer, among other diseases. A major area of scientific research involves understanding the relationships between kinases, their targets, and how the kinome adapts to perturbations of the cellular system. This review will discuss many of the current and developing methods for studying kinase activity, and evaluate their applications, advantages, and disadvantages. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 7
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    PKMYT1: a forgotten member of the WEE1 family (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Print ISSN: 1474-1776
    Electronic ISSN: 1474-1784
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer Nature
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  • 8
    Electronic Resource
    Electronic Resource
    Evidence for selection following perturbation of allozyme frequencies in a natural population of Drosophila (1980)
    [s.l.] : Nature Publishing Group
    Nature 284 (1980), S. 166-168 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The loci chosen for perturbation were esterase-2 (Est-2), pyranosidase (Pyr) and alcohol dehydrogenase-1 (Adh-l), which are on different chromosomes. The only known chromosome inversions are on the second chromosome13, and although Est-2 is also on this chromosome, its precise relationship to the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/284166a0
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  • 9
    Electronic Resource
    Electronic Resource
    Kinetics and metabolism of (+)-, (−)- and (±)-bufuralol (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 529-533 
    Details
    ISSN: 1432-1041
    Keywords: beta-blocker ; bufuralol ; enantiomers ; kinetics ; metabolism ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Single oral doses of (+)-, (−)- and (±)-bufuralol were administered to a healthy volunteer to compare the disposition and metabolism of the individual isomers and the racemate. Plasma levels and area under plasma curve (AUC) of the active isomer, (−)-bufuralol, were higher than those of the (+)-isomer; plasma clearance was correspondingly lower. Intermediate values were found for the racemate. The elimination half-life of (−)-bufuralol was shorter than that of (+)-bufuralol, but similar to the racemate. Both isomers were cleared almost entirely by metabolism. The main metabolic pathway for (−)-bufuralol was aromatic hydroxylation, whereas the principal route for (+)-bufuralol was conjugation. Phenol metabolites in the systemic circulation were present mainly as conjugates. Both isomers also underwent aliphatic hydroxylation. This pathway was more favoured by the (+)-isomer, although plasma levels and AUC of the principal product, 2′-hydroxy-bufuralol, were almost identical for the two forms. Major differences in metabolic fate thus had relatively little effect on the disposition of pharmacologically active metabolites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637501
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  • 10
    Electronic Resource
    Electronic Resource
    The ecology of the yeast flora in necroticOpuntia cacti and of associatedDrosophila in Australia (1984)
    Springer
    Microbial ecology 10 (1984), S. 379-399 
    Details
    ISSN: 1432-184X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A survey was made of the yeast communities isolated from necrotic tissue of 4 species of prickly-pear cacti (Opuntia stricta, O. tomentosa, O. monacantha, andO. streptacantha) which have colonized in Australia. Yeast communities were sampled from a number of localities and at different times. Cactus specific yeasts accounted for 80% of the total isolates, and the 3 most common species contributed 63% of the total. Comparisons of the species compositions of the yeast communities indicated that the differences among communities were greater betweenOpuntia species than between different localities within a single cactus species, and also that differences between years were greater than average differences between localities within years. Multivariate statistical tests of association between yeast community and physical features of rots indicated that temperature, pH, and age of rot all exerted some influence on the structure of the yeast community. Similar analyses involvingDrosophila species inhabiting these cactus rots suggested the existence of complex associations betweenDrosophila community, yeast community, and physical and chemical attributes of the cactus necroses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02015562
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