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  • 1
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    The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-02-23
    Description: The alpha subunit of p21(RAS) farnesyltransferase (FNTA), which is also shared by geranylgeranyltransferase, was isolated as a specific cytoplasmic interactor of the transforming growth factor-beta (TGF-beta) and activin type I receptors with the use of the yeast two-hybrid system. FNTA interacts specifically with ligand-free TGF-beta type l receptor but is phosphorylated and released upon ligand binding. Furthermore, the release is dependent on the kinase activity of the TGF-beta type II receptor. Thus, the growth inhibitory and differentiative pathways activated by TGF-beta and activin involve novel mechanisms of serine-threonine receptor phosphorylation-dependent release of cytoplasmic interactors and regulation of the activation of small G proteins, such as p21(RAS).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, T -- Danielson, P D -- Li, B Y -- Shah, P C -- Kim, S D -- Donahoe, P K -- HD28138/HD/NICHD NIH HHS/ -- R01 HD3081/HD/NICHD NIH HHS/ -- R01 HD32112/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1996 Feb 23;271(5252):1120-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8599089" target="_blank"〉PubMed〈/a〉
    Keywords: Activin Receptors ; *Activin Receptors, Type I ; Activins ; *Alkyl and Aryl Transferases ; Amino Acid Sequence ; Animals ; Base Sequence ; Cell Line ; Humans ; Inhibins/*metabolism ; Ligands ; Molecular Sequence Data ; Mutation ; Phosphorylation ; Protein-Serine-Threonine Kinases/chemistry/genetics/*metabolism ; Receptors, Growth Factor/metabolism ; Receptors, Transforming Growth Factor beta/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Transferases/*metabolism ; Transforming Growth Factor beta/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Application of the finite Hankel transform to a diffusion problem without azimuthal symmetry (1994)
    Springer
    Transport in porous media 14 (1994), S. 247-264 
    Details
    ISSN: 1573-1634
    Keywords: Finite Hankel transform ; azimuthal asymmetry ; diffusion equation ; analytic solution ; computer evaluation ; layered medium ; integral transform
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract The problem treated in this paper concerns calculating the evolution of the pressure in a single-phase, slightly compressible fluid in a porous medium consisting of communicating layers. The fluid is produced through a point sink located on the side of an otherwise sealed cylindrical wellbore. This location of the sink causes the flow around the wellbore to be azimuthally asymmetric. The problem is solved through successive application of Laplace, finite Fourier and finite Hankel transforms. Although apparently straightforward, this approach leads to serious numerical difficulties. The published form of the inversion formula for the finite Hankel transform leads to inaccurate computation for the higher azimuthal modes even with 128 bit arithmetic. An alternative form is developed which enables accurate evaluation of the solution with the more practical 64 bit arithmetic. The technique for two-layer solution presented here can be directly extended to a problem with a larger number of communicating layers. This is the first instance of successful application of the finite Hankel transform to an azimuthally asymmetric diffusion problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00631004
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    Paper (German National Licenses)
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  • 3
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    Estimating Gene Expression and Codon-Specific Translational Efficiencies, Mutation Biases, and Selection Coefficients from Genomic Data Alone (2015)
    Oxford University Press
    Details
    Publication Date: 2015-06-14
    Description: Extracting biologically meaningful information from the continuing flood of genomic data is a major challenge in the life sciences. Codon usage bias (CUB) is a general feature of most genomes and is thought to reflect the effects of both natural selection for efficient translation and mutation bias. Here we present a mechanistically interpretable, Bayesian model (ribosome overhead costs Stochastic Evolutionary Model of Protein Production Rate [ROC SEMPPR]) to extract meaningful information from patterns of CUB within a genome. ROC SEMPPR is grounded in population genetics and allows us to separate the contributions of mutational biases and natural selection against translational inefficiency on a gene-by-gene and codon-by-codon basis. Until now, the primary disadvantage of similar approaches was the need for genome scale measurements of gene expression. Here, we demonstrate that it is possible to both extract accurate estimates of codon-specific mutation biases and translational efficiencies while simultaneously generating accurate estimates of gene expression, rather than requiring such information. We demonstrate the utility of ROC SEMPPR using the Saccharomyces cerevisiae S288c genome. When we compare our model fits with previous approaches we observe an exceptionally high agreement between estimates of both codon-specific parameters and gene expression levels ( 〉 0.99 in all cases). We also observe strong agreement between our parameter estimates and those derived from alternative data sets. For example, our estimates of mutation bias and those from mutational accumulation experiments are highly correlated ( =0.95 ). Our estimates of codon-specific translational inefficiencies and tRNA copy number-based estimates of ribosome pausing time ( =0.64 ), and mRNA and ribosome profiling footprint-based estimates of gene expression ( =0.53–0.74 ) are also highly correlated, thus supporting the hypothesis that selection against translational inefficiency is an important force driving the evolution of CUB. Surprisingly, we find that for particular amino acids, codon usage in highly expressed genes can still be largely driven by mutation bias and that failing to take mutation bias into account can lead to the misidentification of an amino acid’s "optimal" codon. In conclusion, our method demonstrates that an enormous amount of biologically important information is encoded within genome scale patterns of codon usage, accessing this information does not require gene expression measurements, but instead carefully formulated biologically interpretable models.
    Electronic ISSN: 1759-6653
    Topics: Biology
    Published by Oxford University Press
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  • 4
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    An algorithm for the estimation of upper tropospheric humidity from Kalpana observations: Methodology and validation (2011)
    Wiley
    Details
    Publication Date: 2011-01-13
    Description: This study presents a methodology for estimating the upper tropospheric humidity (UTH) for a layer between 500 and 200 hPa from observations in the water vapor channel (5.6–7.2 μm) of the Indian geostationary satellite, Kalpana. Radiative transfer simulations for different UTH conditions have been used to develop the relationship between water vapor channel radiances and UTH. A new technique has been described to include the normalized reference pressure in the algorithm, to account for latitudinal variation of temperature that is derived from a diverse radiosonde profiles data set and is a polynomial function of the latitude for different months. This has an advantage that the forecast or analysis profiles from the operational numerical weather prediction model are not required to compute the normalized reference pressure. The operationally retrieved UTH products have been extensively compared and validated for the period of 1 March to 1 May 2009, using Meteosat-7 UTH products over the Indian Ocean and the UTH computed from the radiosonde profiles. The results suggest that UTH estimates from Kalpana match very well with the Meteosat-7 UTH products having RMS difference of ∼6%. Validation with the UTH computed from the radiosonde observed relative humidity shows that the RMS error of Kalpana UTH is 9.6% and the mean bias is −3.0%. Similar validation of Meteosat-7 UTH with the same set of radiosonde derived UTH shows an RMS error of 13.3% and the bias of −6.5%, which is higher in comparison to the Kalpana UTH.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 5
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    Application of the finite Hankel transform to a diffusion problem without azimuthal symmetry (1994)
    Springer
    Details
    Publication Date: 1994-03-01
    Print ISSN: 0169-3913
    Electronic ISSN: 1573-1634
    Topics: Geosciences , Technology
    Published by Springer
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  • 6
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    Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription (1997)
    EMBO Press
    Details
    Publication Date: 1997-12-01
    Print ISSN: 0261-4189
    Electronic ISSN: 1460-2075
    Topics: Biology , Medicine
    Published by EMBO Press on behalf of European Molecular Biology Organization.
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  • 7
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    Linear systems analysis program, L224(QR). Volume 1: Engineering and usage (1979)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The QR computer program is described as well as its use in classical control systems analysis and synthesis (root locus, time response, and frequency response).
    Keywords: AIRCRAFT STABILITY AND CONTROL
    Type: NASA-CR-2861
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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