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  • 1
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    Modularity of a carbon-fixing protein organelle [Cell Biology] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-01-12
    Description: Bacterial microcompartments are proteinaceous complexes that catalyze metabolic pathways in a manner reminiscent of organelles. Although microcompartment structure is well understood, much less is known about their assembly and function in vivo. We show here that carboxysomes, CO2-fixing microcompartments encoded by 10 genes, can be heterologously produced in Escherichia coli. Expression of carboxysomes in E. coli resulted in the production of icosahedral complexes similar to those from the native host. In vivo, the complexes were capable of both assembling with carboxysomal proteins and fixing CO2. Characterization of purified synthetic carboxysomes indicated that they were well formed in structure, contained the expected molecular components, and were capable of fixing CO2 in vitro. In addition, we verify association of the postulated pore-forming protein CsoS1D with the carboxysome and show how it may modulate function. We have developed a genetic system capable of producing modular carbon-fixing microcompartments in a heterologous host. In doing so, we lay the groundwork for understanding these elaborate protein complexes and for the synthetic biological engineering of self-assembling molecular structures.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-01-12
    Description: Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savage, Peter A -- Vosseller, Keith -- Kang, Chulho -- Larimore, Kevin -- Riedel, Elyn -- Wojnoonski, Kathleen -- Jungbluth, Achim A -- Allison, James P -- New York, N.Y. -- Science. 2008 Jan 11;319(5860):215-20. doi: 10.1126/science.1148886.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18187659" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/*immunology ; Adoptive Transfer ; Animals ; Antigen Presentation ; Antigens, Neoplasm/*immunology ; Autoantigens/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; Cell Line ; Epitopes, T-Lymphocyte/immunology ; Histones/*immunology ; Hybridomas ; Lymphocytes, Tumor-Infiltrating/*immunology ; Male ; Mice ; Mice, Transgenic ; Peptide Fragments/immunology ; Prostatic Neoplasms/*immunology ; Receptors, Antigen, T-Cell, alpha-beta/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Aire-dependent thymic development of tumor-associated regulatory T cells (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-03-09
    Description: Despite considerable interest in the modulation of tumor-associated Foxp3(+) regulatory T cells (T(regs)) for therapeutic benefit, little is known about the developmental origins of these cells and the nature of the antigens that they recognize. We identified an endogenous population of antigen-specific T(regs) (termed MJ23 T(regs)) found recurrently enriched in the tumors of mice with oncogene-driven prostate cancer. MJ23 T(regs) were not reactive to a tumor-specific antigen but instead recognized a prostate-associated antigen that was present in tumor-free mice. MJ23 T(regs) underwent autoimmune regulator (Aire)-dependent thymic development in both male and female mice. Thus, Aire-mediated expression of peripheral tissue antigens drives the thymic development of a subset of organ-specific T(regs), which are likely coopted by tumors developing within the associated organ.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622085/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622085/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malchow, Sven -- Leventhal, Daniel S -- Nishi, Saki -- Fischer, Benjamin I -- Shen, Lynn -- Paner, Gladell P -- Amit, Ayelet S -- Kang, Chulho -- Geddes, Jenna E -- Allison, James P -- Socci, Nicholas D -- Savage, Peter A -- 1R01CA160371-01/CA/NCI NIH HHS/ -- P30 CA008748/CA/NCI NIH HHS/ -- P30 CA14599/CA/NCI NIH HHS/ -- R01 CA160371/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Mar 8;339(6124):1219-24. doi: 10.1126/science.1233913.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23471412" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD4/analysis ; Antigens, Polyomavirus Transforming/genetics ; Autoantigens/immunology ; Female ; Forkhead Transcription Factors/analysis ; Homeodomain Proteins/genetics ; *Immune Tolerance ; Male ; Mice ; Mice, Transgenic ; Prostate/*immunology ; Prostate-Specific Antigen/immunology ; Prostatic Neoplasms/*immunology ; T-Lymphocytes, Regulatory/*immunology ; Thymus Gland/*growth & development/*immunology ; Transcription Factors/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Aopb systems manual. program description- mystic tracer (1964)
    In:  CASI
    Details
    Publication Date: 2019-05-23
    Description: Mystic Tracer subroutine for debugging programs - computer program
    Keywords: COMPUTERS
    Type: NASA-TM-X-55116 , X-542-64-262
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Ibm 1401 selective tape to card. aopb systems manual, program description (1964)
    In:  CASI
    Details
    Publication Date: 2019-05-23
    Description: IBM 1401 selective tape-to-card computer program
    Keywords: COMPUTERS
    Type: NASA-TM-X-55169 , X-542-64-261
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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